Association between duration of untreated bipolar disorder and clinical outcome: data from a Brazilian sample

Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina
Gustavo C MedeirosKarla M Almeida

Abstract

Bipolar disorder (BD) is often left untreated for long periods, and this delay in treatment correlates with unfavorable prognosis. The present study sought to assess the magnitude of duration of untreated bipolar disorder (DUB) in Brazil. We hypothesized that DUB would be longer in Brazil than in developed countries, and would be associated with poor clinical outcomes. One hundred and fifty-two psychiatric outpatients were evaluated for BD diagnosis, demographics, DUB, and clinical outcomes. The mean age and mean DUB were, respectively, 38.9±10.8 and 10.4±9.8 years. An extended DUB was associated with early onset of BD (p < 0.001), depression as first mood episode (p = 0.04), and presence of BD in a first-degree relative (p = 0.012). Additionally, a longer DUB was associated with poorer clinical outcomes, such as elevated rates of rapid cycling (p = 0.004) and anxiety disorders (p = 0.016), as well as lower levels of current full remission (p = 0.021). As DUB may be a modifiable variable, better medical education regarding mental health, more structured medical services, and population-wide psychoeducation might reduce the time between onset and proper management of BD, thus improving outcome.

References

Oct 14, 2000·Archives of Disease in Childhood·A Bush
Dec 1, 2001·Psychiatric Services : a Journal of the American Psychiatric Association·D A PerlickB G Link
Jul 2, 2003·The American Journal of Psychiatry·Pamela B PeeleDavid J Kupfer
Jun 15, 2005·Bipolar Disorders·Lakshmi N YathamUNKNOWN Canadian Network for Mood and Anxiety Treatments
Dec 2, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Dan ChisholmShekhar Saxena
Jul 20, 2007·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Valentim Gentil
Nov 17, 2009·European Archives of Psychiatry and Clinical Neuroscience·A Carlo AltamuraEmanuela Mundo
Mar 23, 2010·International Clinical Psychopharmacology·Alfredo Carlo AltamuraBernardo Dell'Osso
May 4, 2010·European Psychiatry : the Journal of the Association of European Psychiatrists·C ReedUNKNOWN EMBLEM Advisory Board
Dec 31, 2010·The Journal of Clinical Psychiatry·Marion Leboyer, David J Kupfer
Mar 8, 2011·Bulletin of the World Health Organization·Tim A BrucknerShekhar Saxena
Apr 14, 2012·Journal of Affective Disorders·Marion LeboyerDavid J Kupfer
Aug 21, 2012·Acta Psychiatrica Scandinavica·N DrancourtF Bellivier
Jul 12, 2013·JAMA : the Journal of the American Medical Association·Christopher J L MurrayUNKNOWN U.S. Burden of Disease Collaborators
Aug 12, 2014·Journal of Affective Disorders·Stacey McCrawP B Mitchell
Jan 1, 2013·International Journal of Bipolar Disorders·Chantal HenryUNKNOWN ENBREC study group

❮ Previous
Next ❯

Citations

Jan 24, 2017·Journal of Child and Adolescent Psychopharmacology·Sarah LytleMartha Sajatovic
Jul 28, 2016·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jessica DaganiMatthew Large
Jan 31, 2018·Journal of Child and Adolescent Psychopharmacology·Adriana ForteaInmaculada Baeza
May 9, 2019·Perspectives in Psychiatric Care·Yuan-Yuan WangYu-Tao Xiang
Mar 23, 2017·Scientific Reports·Ling ZhangYu-Tao Xiang
Nov 22, 2019·Bipolar Disorders·Amit ShalevBoris Birmaher
Sep 12, 2020·Research in Psychotherapy : Psychopathology, Process, and Outcome·Marco SolmiCarla Cremonese
Mar 19, 2021·Revista colombiana de psiquiatría·Brayan F LarrahondoDaniel C Aguirre-Acevedo
Jun 9, 2021·Revista Colombiana De Psiquiatría (English Ed.)·Brayan F LarrahondoDaniel C Aguirre-Acevedo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

North Carolina Medical Journal
P R Becherer
Journal of Emergency Nursing : JEN : Official Publication of the Emergency Department Nurses Association
AnnMarie Papa, Cindy Lefton
© 2022 Meta ULC. All rights reserved