Association between early serum cholinesterase activity and 30-day mortality in sepsis-3 patients: A retrospective cohort study

PloS One
Zheng-Liang PengGuo-Zhong Qing

Abstract

Low serum cholinesterase (SCHE) activity has been associated with poor prognoses in a variety of conditions, including sepsis. However, such an association has not been well characterized since the Third International Consensus Definitions Task Force modified the definition of sepsis to "life-threatening organ dysfunction due to a dysregulated host response to infection" (known as sepsis-3) in 2016. In the current retrospective cohort study, we examined whether 30-day mortality in sepsis-3 patients is associated with SCHE activity. A total of 166 sepsis-3 patients receiving treatment at an emergency intensive care unit (EICU) were included. The 30-day death rate was 33.1% (55/166). SCHE activity upon EICU admission was lower in nonsurvivors (3.3 vs. 4.5 KU/L in survivors, p = 0.0002). Subjects with low SCHE activity (defined as <4 KU/L) had higher 30-day mortality rates than subjects with normal SCHE activity (45.5%, 40/88 vs. 19.2%, 15/78; p<0.001). A multivariate logistic regression analysis revealed an association between 30-day mortality and lower SCHE activity after adjustments for relevant factors, such as acute multiple organ dysfunction. The odds ratio (OR) for every unit decrease in SCHE activity was 2.11 (95% confiden...Continue Reading

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Citations

Jun 26, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Paloma Bermejo-BescósCarmen Sánchez-Castellano
Jan 2, 2021·Research in Veterinary Science·Meriç KocatürkZeki Yilmaz
Nov 12, 2021·Journal of Proteome Research·Jason M KinchenKirk L Pappan

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