Association between EBNA2 and LMP1 subtypes of Epstein-Barr virus and nasopharyngeal carcinoma in Thais

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Danai TiwawechTakafumi Ishida

Abstract

Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignancy that is common in Thailand. The association of the EBV nuclear antigen 2 gene (EBNA2) and the latent membrane protein 1 gene (LMP1) with NPC is unclear. To determine the association between EBNA2 and LMP1 subtypes of EBV and NPC in Thais. EBV DNA from blood samples of 75 Thai patients with NPC and 44 age-matched controls was examined by PCR for EBNA2 subtypes (EBV type 1 and type 2) and LMP1 subtypes (wild-type LMP1 (wt-LMP1) and LMP1 containing a 30-bp deletion (del-LMP1)). The frequencies of EBV type 1 in cases (96.0%) and controls (97.7%) were similar. The frequency of del-LMP1 in cases (58.7%) was higher than in controls (36.4%) (p=0.023). Among NPC patients, the frequency of del-LMP1 in stages III and IV (65.6%) was higher than in stages I and II (18.2%) (p=0.006). By analyzing nucleotide sequence of the LMP1 region, a new subtype, Thai1, was identified. LMP1 subtypes of EBV may be involved in NPC susceptibility. The del-LMP1 variant may be a useful molecular marker for early detection, diagnosis and prognosis of Thai patients with NPC.

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Citations

Jul 16, 2010·Archives of Oral Biology·R A P M PereraC S P Tsang
Apr 30, 2010·The Journal of General Virology·Vannarat SaechanTakafumi Ishida
Apr 17, 2015·Journal of Medical Virology·Marco NevesHugo Sousa
Jul 20, 2016·Journal of Medical Virology·Marco NevesHugo Sousa
Dec 31, 2016·The Journal of General Virology·Lu ZhouChun-Kui Shao
Oct 17, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Youyuan YaoYi-Xin Zeng
Sep 20, 2018·Journal of Medical Virology·Supitcha WanvimonsukNakarin Kitkumthorn
Jun 3, 2017·Infectious Agents and Cancer·Sylwia FołtynMałgorzata Polz-Dacewicz
Oct 24, 2012·Integrative Cancer Therapies·Malek A ZihlifSaid I Ismail
Jul 31, 2019·Oxidative Medicine and Cellular Longevity·Małgorzata Strycharz-DudziakMałgorzata Polz-Dacewicz

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