Association between EGFR/KRAS mutation and expression of VEGFA, VEGFR and VEGFR2 in lung adenocarcinoma

Oncology Letters
Xiao-Han YuanKai Li

Abstract

Epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene homolog (KRAS) are two of the most notable driver genes in lung cancer, whilst vascular endothelial growth factor (VEGF) signaling serves a critical function in tumor angiogenesis. However, few studies have focused on the potential connection between EGFR/KRAS mutational status, and VEGFA, VEGF receptor (VEGFR)1 and VEGFR2 expression in lung adenocarcinoma. EGFR (exon 19, 20 and 21) and KRAS (exon 2) mutations were detected using an amplification refractory mutation system technique, and the expression of VEGFA, VEGFR1 and VEGFR2 was analyzed using immunohistochemistry in 204 patients with lung adenocarcinoma. Associations between EGFR/KRAS mutational status and VEGFA, VEGFR1, and VEGFR2 expression was analyzed using Pearson χ2 tests. It was revealed that EGFR 21 exon (P=0.033) and EGFR 20 exon (P=0.002) mutated tumors exhibited a significantly higher level of expression of VEGFA. EGFR 21 exon mutant tumors additionally demonstrated a significantly higher level of co-expression of VEGFA and VEGFR1 (P<0.001). EGFR 19 exon mutation was significantly associated with low levels of VEGFR1 (P=0.008). KRAS mutation was significantly associated with a high l...Continue Reading

References

Sep 26, 2003·Seminars in Surgical Oncology·Merrill J Solan, Maria Werner-Wasik
Dec 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J Hicklin, Lee M Ellis
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tetsuya MitsudomiYasushi Yatabe
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Dec 16, 2005·Nature·Leigh CoultasJanet Rossant
May 16, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Takashi SetoYukito Ichinose
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marcin Kowanetz, Napoleone Ferrara
Sep 28, 2006·Journal of Biochemistry and Molecular Biology·Masabumi Shibuya
Oct 3, 2007·The Journal of Clinical Investigation·Sophie SunJohn D Minna
Feb 16, 2008·Lancet·Alberto MantovaniFrancesco M Marincola
May 3, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Niels ReinmuthMichael Meister
Jul 4, 2008·Nature Reviews. Cancer·Lee M Ellis, Daniel J Hicklin
Feb 24, 2009·Current Opinion in Cell Biology·Marja LohelaKari Alitalo
May 22, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kari ChanskyUNKNOWN International Staging Committee and Participating Institutions
Nov 26, 2009·International Journal of Colorectal Disease·Carl C SchimanskiMartin R Berger
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Nov 17, 2011·World Journal of Clinical Oncology·Ramon Andrade de MelloAntónio Mf Araújo
Jan 31, 2012·The Lancet Oncology·Rafael RosellUNKNOWN Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia T
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Apr 24, 2014·Thyroid : Official Journal of the American Thyroid Association·Veronika MancikovaMercedes Robledo
Oct 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jifu EWei Zhang
Sep 13, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shiyong LiMao Mao

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Apr 12, 2019·Frontiers in Oncology·Shaochuan LiuKai Li
Jul 25, 2021·Cancers·Julien AncelValérian Dormoy

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