Association between endogenous feline leukemia virus loads and exogenous feline leukemia virus infection in domestic cats

Virus Research
Ravi TandonRegina Hofmann-Lehmann

Abstract

Recently, we demonstrated that endogenous feline leukemia virus (enFeLV) loads may vary among cats of different populations and that FeLV-infected cats have higher enFeLV loads than uninfected cats. Thus, we hypothesized that enFeLV might influence the pathogenesis and outcome of FeLV infection. No significant difference in the infection outcome (regressive versus progressive infection) was observed between groups of cats with high or low enFeLV loads following FeLV-A challenge. However, cats with high enFeLV loads showed higher viral replication (plasma viral RNA and p27 antigen levels) than cats with low enFeLV loads in the early phase of the infection. The enFeLV transcription level varied at different time points, but no clear-cut pattern was observed. In conclusion, our results demonstrated an association between enFeLV loads and FeLV replication but not outcome of infection. enFeLV should be considered as an important confounder in experimental FeLV infection or vaccination studies.

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Citations

Oct 9, 2009·Journal of Virology·Sarah A LamereDaniel R Salomon
Jan 10, 2016·Archives of Virology·Hugo RamírezH Alejandro Martínez
Dec 17, 2009·Veterinary Immunology and Immunopathology·Andrea N TorresEdward A Hoover
Sep 6, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·A Katrin Helfer-HungerbuehlerRegina Hofmann-Lehmann
Dec 3, 2016·The Journal of General Virology·Andrea M SpiriBarbara Willi
Mar 10, 2012·Journal of Feline Medicine and Surgery·Theresa EnglertKatrin Hartmann
Dec 9, 2020·Annual Review of Animal Biosciences·Elliott S Chiu, Sue VandeWoude
Mar 7, 2021·Animals : an Open Access Journal From MDPI·Fernando NájeraJosé Jiménez
Jul 7, 2021·Comparative Immunology, Microbiology and Infectious Diseases·Dilek MuzMustafa Necati Muz
Aug 29, 2021·Viruses·A Katrin Helfer-HungerbuehlerRegina Hofmann-Lehmann

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