Association between ESR1 and ESR2 gene polymorphisms and hyperlipidemia in Chinese Han postmenopausal women.

Journal of Human Genetics
Teng ZhaoHe Xu

Abstract

Estrogen was considered to be an important protective factor for cardiovascular diseases in women. Genetic association studies suggested that variations of ESR1and ESR2 genes might have a potential role in lipid profile. Our study aimed to investigate the association of single-nucleotide polymorphisms (SNPs) of ESR1 and ESR2 with hyperlipidemia in Chinese Han postmenopausal women. A total of 443 postmenopausal women aged between 55 and 71 years were recruited from Shanghai, China for a case-control study (154 women with hyperlipidemia and 289 controls). We measured plasma estradiol concentration, glucose and lipid profile levels, evaluated their lifestyle and sequenced four SNPs, namely PvuII (rs2234693) and XbaI (rs9340799) of ESR1 and 1082A>G (rs1256049) and 1730A>G (rs4986938) of ESR2. PvuII (rs2234693) and XbaI (rs9340799) showed significantly different distributions between cases and controls (P=0.002 and P=0.023, respectively). In addition, haplotypes constructed from PvuII-XbaI were also associated with hyperlipidemia (global P=0.012). Haplotypes T-A (P=0.005, odds ratio (OR) 1.52, 95% confidence interval (95% CI): 1.13-2.05) and C-G (P=0.010, OR 0.62, 95% CI: 0.43-0.89) had susceptible and protective effects, respective...Continue Reading

References

Oct 1, 1976·Annals of Internal Medicine·W B KannelT Gordon
Jul 16, 1996·Biochemical and Biophysical Research Communications·L Di CroceA Trentalance
Dec 2, 1998·Basic Research in Cardiology·S R Maxwell
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
Feb 24, 2001·Journal of Human Genetics·S OgawaS Inoue
Mar 15, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Terho LehtimäkiPekka J Karhunen
Jun 27, 2002·The American Journal of Cardiology·Michael E Mendelsohn
Oct 18, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Valeria FerreroWilliam Wijns
Nov 6, 2003·JAMA : the Journal of the American Medical Association·Amanda M ShearmanDaniel Levy
Dec 31, 2003·Molecular Psychiatry·M NilssonK Dahlman-Wright
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Stephanie C E SchuitHuibert A P Pols
Jun 24, 2004·JAMA : the Journal of the American Medical Association·Stephanie C E SchuitAndré G Uitterlinden
Aug 16, 2005·Archives of Medical Research·Antonio de Padua MansurJosé Antonio F Ramires
Sep 24, 2005·Stroke; a Journal of Cerebral Circulation·Amanda M ShearmanGeorge J Miller
Dec 23, 2006·Thrombosis Research·Aline Morandi AléssioJoyce Maria Annichino-Bizzacchi
Aug 24, 2007·Clinical Pharmacology and Therapeutics·N I NtukidemUNKNOWN Consortium on Breast Cancer Pharmacogenomics
Mar 25, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaaki TamuraTatsuo Yamamoto
Apr 15, 2008·Dementia and Geriatric Cognitive Disorders·Nicole SchupfWayne Silverman
May 20, 2008·Clinical Chemistry·Sophie Domingues-MontanariMariano Sentí
Jun 28, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Haiying XuYunfeng Han
Oct 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tim LahmDaniel R Meldrum

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Citations

Apr 30, 2014·DNA and Cell Biology·Hong-Hua GaoJia-Mei Wen
Jan 6, 2011·Current Opinion in Lipidology·Dino Rotondo, Jillian Davidson
Feb 14, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Lisiane SmiderleSilvana Almeida

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