Association between exposure to anaesthesia and surgery and long-term cognitive trajectories in older adults: report from the Mayo Clinic Study of Aging

British Journal of Anaesthesia
P J SchulteJ Sprung

Abstract

The link between exposure to general anaesthesia and surgery (exposure) and cognitive decline in older adults is debated. We hypothesised that it is associated with cognitive decline. We analysed the longitudinal cognitive function trajectory in a cohort of older adults. Models assessed the rate of change in cognition over time, and its association with exposure to anaesthesia and surgery. Analyses assessed whether exposure in the 20 yr before enrolment is associated with cognitive decline when compared with those unexposed, and whether post-enrolment exposure is associated with a change in cognition in those unexposed before enrolment. We included 1819 subjects with median (25th and 75th percentiles) follow-up of 5.1 (2.7-7.6) yr and 4 (3-6) cognitive assessments. Exposure in the previous 20 yr was associated with a greater negative slope compared with not exposed (slope: -0.077 vs -0.059; difference: -0.018; 95% confidence interval: -0.032, -0.003; P=0.015). Post-enrolment exposure in those previously unexposed was associated with a change in slope after exposure (slope: -0.100 vs -0.059 for post-exposure vs pre-exposure, respectively; difference: -0.041; 95% confidence interval: -0.074, -0.008; P=0.016). Cognitive impairment...Continue Reading

Citations

Jan 29, 2019·Journal of Neurosurgical Anesthesiology·Jeffrey J Pasternak
Feb 20, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Lars I ErikssonNancy L Pedersen
Sep 10, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Juraj SprungDavid O Warner
Oct 28, 2019·Current Opinion in Psychiatry·Lucia Chinnappa-QuinnPerminder S Sachdev
Jan 10, 2020·Nature Protocols·I BellantuonoD W Lamming
Oct 3, 2019·International Anesthesiology Clinics·Christina A RiccioDella M Lin
May 3, 2019·Current Opinion in Anaesthesiology·Timothy G Gaulton
Oct 28, 2019·Anesthesia and Analgesia·Juraj SprungDavid O Warner
May 21, 2019·Critical Care Medicine·Phillip J SchulteJuraj Sprung
Apr 11, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Juraj SprungDavid O Warner
Mar 31, 2020·Journal of Anesthesia·S Chandralekha KruthiventiToby N Weingarten
Dec 14, 2019·Anesthesiology·Roderic G EckenhoffMaryellen F Eckenhoff
Dec 25, 2019·Anaesthesia Critical Care & Pain Medicine·Anne-Claire LukaszewiczVincent Bruckert
Nov 1, 2020·Journal of the American Geriatrics Society·Juraj SprungDavid O Warner
Dec 18, 2020·Frontiers in Genetics·Biswapriya B Misra
Dec 17, 2019·British Journal of Anaesthesia·Elizabeth L WhitlockMichael S Avidan
Dec 20, 2020·Journal of Critical Care·Juraj SprungPrashanthi Vemuri
Mar 30, 2021·Anesthesia and Analgesia·Brina SnyderThomas F Floyd
Jul 29, 2021·Brain, Behavior, and Immunity·Mitchell S V ElkindMady Hornig
Jul 22, 2020·British Journal of Anaesthesia·Keenan A WalkerCharles H Brown
Sep 7, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Aarno Dietz, Thomas Lenarz
Jun 18, 2021·Minerva anestesiologica·Andrea Gentili
Feb 2, 2022·Experimental Gerontology·Pauline GlasmanUNKNOWN INSIGHT-PreAD study group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.