Association between expression of immunoglobulin G-binding proteins by group A streptococci and virulence in a mouse skin infection model.

Infection and Immunity
R Raeder, M D Boyle

Abstract

In this study, we developed a mouse model of skin infection to test the association between expression of immunoglobulin-binding proteins by and infectivity of group A streptococci. Group A streptococci capable of crossing tissue barriers and establishing a lethal systemic infection in mice showed a higher level of immunoglobulin-binding protein expression. The group A streptococci recovered from the spleen of a mouse that died following a skin infection were found to be more virulent when injected into the skin of naive mice. Together, these results suggest that immunoglobulin-binding protein expression by group A streptococci correlates with their ability to establish invasive skin infections.

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Citations

Aug 1, 1994·European Journal of Clinical Investigation·J E TaylorJ A Goodacre
May 17, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manisha PandeyMichael F Good
Sep 17, 2016·Nature Communications·John A LeesJukka Corander
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Jun 20, 2002·Veterinary Immunology and Immunopathology·L B Corbeil
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Sep 5, 2002·Biochemical and Biophysical Research Communications·Shigetada KawabataShigeyuki Hamada
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Aug 1, 1995·Infection and Immunity·H P Müller, L K Rantamäki
Jan 1, 1995·Infection and Immunity·A PodbielskiJ Weber-Heynemann
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham

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