PMID: 9527267Apr 4, 1998Paper

Association between extent of axillary lymph node dissection and survival in patients with stage I breast cancer

Annals of Surgical Oncology
J A SosaM A Zeiger

Abstract

The role of axillary lymph node dissection for stage I (T1N0) breast cancer remains controversial because patients can receive adjuvant chemotherapy regardless of their nodal status and because its therapeutic benefit is in question. The purpose of this study was to determine whether extent of axillary dissection in patients with T1N0 disease is associated with survival. Data from 464 patients with T1N0 breast cancer who underwent axillary dissection from 1973 to 1994 were examined retrospectively. Kaplan-Meier estimates of overall survival, disease-free survival, and recurrence were calculated for patients according to the number of lymph nodes removed (<10 or > or = 10; <15 or > or = 15), and survival curves compared using the Wilcoxon-Gehan statistic. Cox proportional hazards regression modelling was used to adjust for confounding prognostic variables. Median follow-up time was 6.4 years. Patient groups were similar in age, menopausal status, tumor size, hormonal receptor status, type of surgery, and adjuvant therapy. There was a statistically significant improvement in disease-free survival in the > or = 10 versus <10 nodal groups (P <.01). Five-year estimates of survival were 75.7% and 86.2% for <10 nodes and > or = 10 nod...Continue Reading

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Citations

Jul 20, 2000·The Australian and New Zealand Journal of Surgery·A J Spillane, N P Sacks
Nov 20, 2004·Breast Cancer : the Journal of the Japanese Breast Cancer Society·David KragThomas Julian
Jan 2, 2007·Obstetrics and Gynecology·John K ChanKathryn Osann
Dec 5, 2002·Breast Cancer Research and Treatment·Masakuni Noguchi
Aug 19, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Juan C GutierrezLeonidas G Koniaris
Oct 3, 2008·Annals of Surgical Oncology·T CilC M B Holloway
Apr 25, 2000·The Australian and New Zealand Journal of Surgery·P Crowe, W Temple
Aug 6, 2003·Annals of Surgical Oncology·Tzu-Chieh ChaoShin-Cheh Chen
Nov 5, 2003·Annals of Surgical Oncology·F C WrightD R McCready
May 4, 2005·Breast Cancer Research and Treatment·Sue A Joslyn, Badrinath R Konety
May 18, 2004·ANZ Journal of Surgery·Andrew Spillane
Sep 24, 2010·Cancer·Monjri ShahJason D Wright
Oct 8, 2011·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Prapaporn SuprasertSurapan Khunamornpong
Sep 24, 1999·Annals of Surgical Oncology·G B MannK J Van Zee
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