Association between Factor V Gene Polymorphism and Risk of Ischemic Stroke: An Updated Meta-Analysis

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Adel Ali AlhazzaniMagdy Selim

Abstract

Ischemic stroke is a complex, multifactorial, and polygenic disease. Reports on relationship between Factor V G1691A single nucleotide gene polymorphism and ischemic stroke have revealed inconsistent results. We conducted an updated meta-analysis to determine the role of Factor V single nucleotide gene polymorphism in ischemic stroke. We searched the literature using academic electronic databases that is, PubMed, Trip Data Base, EBSCO, and Google Scholar, last search up to September 2017. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from fixed or random effects models whichever applicable using software STATA version 13 (StataCorp LP, College Station, TX). Forty case-control studies met the inclusion criteria, which included 6860 cases and 18,025 controls. Altogether, 19 studies in young adults (age < or = 40 years) and 17 studies were conducted in old stroke (age > 40). Four studies did not report the mean age at recruitment. Significant association between Factor V G1691A gene polymorphism and risk of ischemic stroke were observed under dominant model (OR 1.40; 95% CI: 1.22 to 1.62, P value <.001). Stratified analysis suggested substantial association of Factor V gene polymorphism and risk of is...Continue Reading

Citations

Apr 1, 2020·Continuum : Lifelong Learning in Neurology·Jukka Putaala
Mar 21, 2020·Frontiers in Psychiatry·Yongzheng HanXiangyang Guo
Jan 1, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·L T KhasanovaN A Shamalov

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