PMID: 26885902Feb 18, 2016Paper

Association between FADS1 rs174537 polymorphism and serum proteins in patients with aggressive periodontitis

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
W L SongH X Meng

Abstract

To investigate the potential association between FADS1 rs174537 polymorphism and serum proteins in patients with aggressive periodontitis, which may provide benefits for diagnosis and treatment of aggressive periodontitis. A total of 353 patients with aggressive periodontitis (group AgP) and 125 matched controls (group HP) were recruited in the study. Genotyping of FADS1 rs174537 and serum biochemical indexes were tested at the study's start. The relationships between the levels of TP, GLB, ALB, A/G and genotyping were analyzed. (1) The detection rate of allele G in group AgP was higher than that in group HP(68.1% vs. 61.2%, P=0.046,OR=1.35,95% CI 1.00-1.83); the detection rate of genotype GG in group AgP was higher than in group HP(45.5% vs. 34.4%,P=0.029, OR=1.60, 95% CI 1.05-2.44). (2) In group AgP, the patients with GG genotype exhibited significantly lower TP, GLB than the patients with GT+TT genotype [(77.08±7.88) g/L vs. (79.00±4.66) g/L, P=0.007; (28.17±7.63) g/L vs.(29.88±3.49) g/L,P=0.007) and the higher A/G(1.72±0.22 vs.1.67±0.22, P=0.040), but there was no significant difference in ALB between the patients with GG genotype and the patients with GT+TT genotype. In group HP, there were no significant differences in TP...Continue Reading

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