Association between Fetal MTHFR A1298C (rs1801131) Polymorphism and Neural Tube Defects Risk: A Systematic Review and Meta-Analysis.

Fetal and Pediatric Pathology
Sara Soleimani-JadidiHossein Neamatzadeh

Abstract

The association of the fetal MTHFR A1298C (rs1801131) polymorphism and neural tube defects (NTDs) susceptibility has been widely demonstrated, but the results remain inconclusive. Thus, we performed a meta-analysis to investigate the association between fetal MTHFR A1298C polymorphism and NTDs risk. An electronic search of PubMed, web of science, SciELO, CNKI database for studies on the fetal MTHFR A1298C polymorphism and NTDs risk was performed up to March 30, 2020. A total of 22 case-control studies with 3,224 fetuses with NTDs and 3,295 controls were selected. Overall, pooled data showed that the fetal MTHFR A1298C polymorphism was not significantly associated with risk an increased risk of NTDs in the global population. When stratified analysis by ethnicity, country of origin and NTDs type, still no statistically significant association was found. Our pooled data emerged no evidence for significant association between fetal MTHFR A1298C polymorphism and NTDs risk.

References

May 1, 1974·British Medical Bulletin·I Leck
Feb 1, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T K Eskes, R P Steegers-Theunissen
Mar 7, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Andrea L A CunhaRosario D C Hirata
Jul 12, 2002·Journal of Human Genetics·Patrizia De MarcoValeria Capra
May 6, 2003·Journal of Human Genetics·Anne Parle-McDermottLawrence C Brody
Jul 20, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Têmis Maria FélixRoberto Giugliani
Aug 18, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Ahmad Hamim SadewaHisahide Nishio
Jul 11, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lizbeth Gonzalez-HerreraDoris Pinto-Escalante
Oct 22, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Kristen L DeakUNKNOWN NTD Collaborative Group
Apr 27, 2010·Developmental Disabilities Research Reviews·Kit Sing AuHope Northrup
Jul 31, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jana BehunovaLudmila Podracka
Jan 24, 2012·American Journal of Obstetrics and Gynecology·Xi W WangYu L Cheng
Jul 4, 2012·Indian Journal of Human Genetics·Laxmi V Yaliwal, Rathnamala M Desai
Jun 25, 2013·Lancet Neurology·Andrew J CoppNicholas D E Greene
Oct 2, 2013·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Eduardo Borges da FonsecaMarcelo Zugaib
Jul 18, 2014·Annual Review of Neuroscience·Nicholas D E Greene, Andrew J Copp
Aug 20, 2014·Journal of Biomedical Science·Subit BaruaMohammed A Junaid
Nov 27, 2014·Revista médica de Chile·Rosa PardoEva Tapia
Apr 10, 2015·Metabolic Brain Disease·Yongxin WangZengliang Wang
Aug 15, 2015·Journal of Clinical Pharmacology·David ChitayatGideon Koren
Jul 12, 2016·Paediatrics & Child Health·Noam AmiUNKNOWN Canadian Paediatric Society, Drug Therapy and Hazardous Substances Committee
Nov 30, 2018·Asian Pacific Journal of Cancer Prevention : APJCP·Mansour MoghimiJalal Sadeghizadeh- Yazdi
May 30, 2019·Arquivos De Gastroenterologia·Majid AflatoonianHossein Neamatzadeh
Jul 28, 2019·Asian Pacific Journal of Cancer Prevention : APJCP·Jamal Jafari-NedooshanHossein Neamatzadeh
Sep 17, 2019·International Journal of Medical Sciences·Paolo CastigliaMaria Rosaria Muroni
Oct 16, 2019·Klinická onkologie : casopis Ceské a Slovenské onkologické spolecnosti·Mohsen GohariHossein Neamatzadeh

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