Association between FKBP5 polymorphisms and depressive disorders or suicidal behavior: A systematic review and meta-analysis study

Psychiatry Research
Yazmín Hernández-DíazAlma Delia Genis-Mendoza

Abstract

Psychiatric disorders are complex polygenic diseases that show common genetic vulnerability. Several studies have investigated the association of polymorphisms of FK506 binding protein 51 (FKBP5) gene and depressive disorders or suicidal behavior, however, the results have been controversial and ambiguous. The aim of our study was to explore the role of the FKBP5 gene variants (rs1360780, rs3800373 and rs4713916), in depressive disorders or suicidal behavior through a systematic review and a meta-analysis. The protocol number of the study is PROSPERO CRD42018089295. The meta-analysis included 12 studies. Odds ratios with 95% confidence intervals were used to evaluate the association and the publication bias was tested by Egger's test and funnel plot; heterogeneity was assessed by the Cochran's chi-square-based Q statistic test and the inconsistency index. Our results showed that the rs3800373 and rs4713916 were associated with an increased risk of depressive disorders when using the heterozygous and dominant models. In the stratified analysis by ethnicity, a significantly increased risk of depressive disorders was also observed for rs3800373 and rs4713916 in Caucasians. When we analyzed suicidal behavior, we found a significant...Continue Reading

Citations

Nov 12, 2019·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Gabriel IvbijaroYaccub Enum
Dec 24, 2019·Cranio : the Journal of Craniomandibular Practice·Rafaela ScariotJoão Cesar Zielak
Mar 27, 2020·Psychiatry Investigation·Laura OrsoliniDomenico De Berardis
Nov 19, 2020·Brazilian Oral Research·Giselle Emilãine da Silva ReisRafaela Scariot
Nov 9, 2020·Brain Research Bulletin·Yazmín Hernández-DíazAlma Delia Genis-Mendoza
Jul 3, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Sura F AlsaffarHaider F Ghazi
Dec 5, 2019·Journal of Medicinal Chemistry·Xixi FengFelix Hausch

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