Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults

Revista médica de Chile
Fanny PetermannC Celis-Morales

Abstract

Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. To investigate the association of FTO gene with adiposity markers in Chilean adults. 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.

Citations

Sep 8, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carol Barahona PonceJusto Lorenzo Bermejo
Apr 29, 2021·Archives of Endocrinology and Metabolism·Lorena MardonesUNKNOWN ELHOC group (Epidemiology of Lifestyle and Health Outcomes in Chile)
Aug 4, 2021·Endocrinología, Diabetes Y Nutrición·Lorena MardonesUNKNOWN en representación del grupo de investigación ELHOC (Epidemiology of Lifestyle, Health Outcomes in Chile)

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