Association between furosemide administration and outcomes in critically ill patients with acute kidney injury

Critical Care : the Official Journal of the Critical Care Forum
Guang-Ju ZhaoZhong-Qiu Lu

Abstract

Although current guidelines for AKI suggested against the use of furosemide in AKI management, the effect of furosemide on outcomes in real-world clinical settings remains uncertain. The aim of the present study was to investigate the association between furosemide administration and outcomes in critically ill patients with AKI using real-world data. Critically ill patients with AKI were identified from the Medical Information Mart for Intensive Care (MIMIC)-III database. Propensity score (PS) matched analysis was used to match patients receiving furosemide to those without diuretics treatment. Linear regression, logistic regression model, and Cox proportional hazards model were used to assess the associations between furosemide and length of stay, recovery of renal function, and in-hospital and 90-day mortality, respectively. A total of 14,154 AKI patients were included in the data analysis. After PS matching, 4427 pairs of patients were matched between the patients who received furosemide and those without diuretics treatment. Furosemide was associated with reduced in-hospital mortality [hazard ratio (HR) 0.67; 95% CI 0.61-0.74; P < 0.001] and 90-day mortality [HR 0.69; 95% CI 0.64-0.75; P < 0.001], and it was also associated...Continue Reading

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Citations

May 27, 2020·Critical Care : the Official Journal of the Critical Care Forum·Shaowei GaoZhongxing Wang
Nov 14, 2020·Anesthesia and Analgesia·Khaschayar Saadat-GilaniMelanie Meersch
Mar 3, 2021·The American Journal of Emergency Medicine·Yiping WangZhongqiu Lu
Apr 4, 2021·Journal of Clinical Medicine·Emaad M Abdel-RahmanSamir C Gautam
Jul 15, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffrey Segar, Jennifer G Jetton

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