Association between Furosemide Exposure and Patent Ductus Arteriosus in Hospitalized Infants of Very Low Birth Weight.

The Journal of Pediatrics
Elizabeth J ThompsonChristoph P Hornik

Abstract

To evaluate the association between furosemide exposure and patent ductus arteriosus (PDA) in a large, contemporary cohort of hospitalized infants with very low birth weight (VLBW). Using the Pediatrix Medical Group Clinical Data Warehouse, we identified all inborn infants of VLBW <37 weeks of gestation discharged from the neonatal intensive care unit after the first postnatal week from 2011 to 2015. We defined PDA as any medical (ibuprofen or indomethacin) or surgical PDA therapy. We collected data up to the day of PDA treatment or postnatal day 18 for infants not diagnosed with PDA. We performed multivariable logistic regression to evaluate the association between PDA and exposure to furosemide. We included 43 576 infants from 337 neonatal intensive care units, of whom 6675 (15%) underwent PDA treatment. Infants with PDA were more premature and more often exposed to mechanical ventilation and inotropes. Furosemide was prescribed to 4055 (9%) infants. On multivariable regression, exposure to furosemide was associated with decreased odds of PDA treatment (OR 0.72; 95% CI 0.65-0.79). Increasing percentage of days with furosemide exposure was not associated with PDA treatment (OR 1.01; 95% CI 0.97-1.06). Furosemide exposure was n...Continue Reading

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Aug 19, 2020·Acta Paediatrica·Janina MarissenUNKNOWN German Neonatal Network
Jan 23, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jean-Pierre Guignard, Silvia Iacobelli
Jan 8, 2021·Frontiers in Pediatrics·Flaminia BardanzelluVassilios Fanos
Mar 7, 2021·Seminars in Fetal & Neonatal Medicine·Amir M Zayegh, Peter G Davis
May 4, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Joana SantosHercília Guimarães

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