Abstract
Vascular endothelial growth factor (VEGF) has been suggested to be a key mediator in the development of atopy and T(H)2 inflammation. We sought to evaluate the effects of variations in the gene coding VEGF receptor (VEGFR) 2 on intermediate phenotypes of asthma in the Korean population. A cohort of 2055 children and adolescents responded to a questionnaire concerning asthma symptoms and risk factors and underwent methacholine bronchial challenge and skin tests. The VEGFR2 gene, including the promoter area, was sequenced on 24 healthy subjects to discover informative single nucleotide polymorphisms (SNPs; minor allele frequency >2%). After haplotype reconstruction, 4 tagging SNPs (IVS6+54A>G, +889G>A, +1416T>A, and IVS25-92G>A) were scored. These SNPs were also scored in 480 adult asthmatic patients to verify the above genetic association study. The prevalence of atopy was associated with a single SNP (+889G>A) of VEGFR2 with borderline significance (P = .048; relative risk, 1.13; 95% CI, 1.00-1.28). However, haplotype analysis showed that the atopy prevalence was strongly associated with a haplotype (AGAG) of VEGFR2 (P = .002; relative risk, 1.25; 95% CI, 1.09-1.42). As for airway hyperresponsiveness, neither individual SNPs no...Continue Reading
Citations
Jun 24, 2010·Cancer Causes & Control : CCC·LaCreis R KiddJames L Wittliff
Jan 26, 2012·Journal of Molecular Neuroscience : MN·Hongyan ChenDaru Lu
Oct 31, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D H KimJ H Lipton
Dec 14, 2011·Cornea·Hamid HosseiniMahmood Nejabat
Nov 24, 2006·Thorax·Heung-Woo ParkSang-Heon Cho
Mar 24, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Bangwei CaoChangqing Xu
Dec 26, 2006·Pharmacogenomics·Giuseppe PasqualettiGuido Bocci
Nov 20, 2009·Investigational New Drugs·Neeltje SteeghsHenk-Jan Guchelaar
May 20, 2008·Human Immunology·Emmanouil GalanakisGeorge N Goulielmos
Jul 6, 2007·The Journal of Allergy and Clinical Immunology·Fred D Finkelman, Donata Vercelli
Apr 14, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y-K KimY-Y Kim
Jul 11, 2007·Allergy·J-H NamkungJ-M Yang
Jun 4, 2008·Genetic Epidemiology·Shwu-Fan MaJoe G N Garcia
Feb 3, 2009·Allergy·H-W ParkS-H Cho
Mar 5, 2008·Allergy·H-K ParkY-K Kim
Nov 13, 2009·The Prostate·Tiva T VanCleaveLa Creis R Kidd
Oct 3, 2009·Allergy·J RenkonenR Renkonen
Sep 26, 2008·Respiratory Medicine·Heung-Woo ParkSang-Heon Cho
Nov 21, 2012·Journal of Affective Disorders·Piotr GałeckiJanusz Szemraj
Jan 31, 2018·Clinical and Experimental Dermatology·N Y YoonE H Choi
Jul 2, 2010·Allergy, Asthma & Immunology Research·Sang Heon Cho
Jul 2, 2010·Allergy, Asthma & Immunology Research·You-Young Kim
Aug 14, 2019·Biomolecules·Agnieszka Paradowska-GoryckaMarzena Olesinska
Dec 7, 2013·The Korean Journal of Internal Medicine·Min-Hye KimHeung-Woo Park
Sep 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·You-Sun KimYoon-Keun Kim
Apr 21, 2018·Allergy, Asthma & Immunology Research·Myungsoo JunEung Ho Choi