Association between gentamicin resistance and stress tolerance in water isolates of Ralstonia pickettii and R. mannitolilytica

Folia Microbiologica
Pompeyo FerroCélia M Manaia

Abstract

Members of the species Ralstonia pickettii and R. mannitolilytica, although ubiquitous and lacking major virulence factors, have been associated with nosocomial outbreaks. Tolerance to metals, antibiotics, and disinfectants may represent an advantage for their ubiquity and opportunistic pathogenic potential. In this study, we compared five strains that differed on the origin (hospital effluent, tap water, mineral water) and in the susceptibility to aminoglycosides, regarding their tolerance to metals and disinfection. The growth kinetics and biofilm formation capacity were tested in four R. pickettii strains and one R. mannitolilytica at sub-inhibitory concentrations of aminoglycosides or arsenite. The survival to UV radiation, chlorine, or hydrogen peroxide was also compared in aminoglycoside resistant and susceptible strains. Aminoglycoside-resistant strains presented a higher tolerance to arsenite than the susceptible ones and either aminoglycosides or arsenite was observed to stimulate the biofilm formation. Sub-inhibitory concentrations of the aminoglycoside gentamicin or arsenite significantly decreased the growth rate and yield, but only arsenite caused a significant increase of the lag phase. Hydrogen peroxide presented...Continue Reading

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Citations

Nov 7, 2019·Critical Reviews in Microbiology·Pompeyo FerroCélia M Manaia
May 2, 2020·Journal of Applied Microbiology·Nancy Ahmed SelimMohamed Khaled Ibrahim
Apr 5, 2020·Scientific Reports·Philip G HamillJohn E Hallsworth
Nov 17, 2020·Research in Microbiology·Pompeyo FerroCélia M Manaia

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BETA
PCA

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iTol
SPSS
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MEGA6

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