PMID: 11333120May 3, 2001Paper

Association between germ cell tumours, large numbers of naevi, atypical naevi and melanoma

Melanoma Research
M F AvrilC Théodore

Abstract

Identifying groups of subjects at high risk for the development of melanoma is crucial for the early diagnosis of curable tumours. In the present study, we performed a skin examination in a group of 63 patients followed up after treatment of germ cell tumours (GCTs) who were referred to the dermatologist for multiple pigmented cutaneous spots. Forty-nine patients bearing a great number of naevi or atypical naevi were included in the study. Two thin cutaneous melanomas were discovered in two patients. In addition, a third patient had had a conjunctival melanoma since treatment of the GCT. Our study confirms the presence of atypical naevi in a subgroup of GCT patients, who are shown to be at high risk of developing melanoma. Patients harbouring multiple pigmented spots should be referred for a skin examination aimed at early detection of curable melanomas, and should be advised to protect themselves from sun exposure.

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Citations

Jul 22, 2009·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Xiao-gen HuQing-hua Yang
Jan 8, 2004·British Journal of Cancer·Ch TheodoreP Wibault
Feb 6, 2003·Cancer·Martijn F Lutke HolzikHarald J Hoekstra

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