Association between Helicobacter pylori and gastric carcinoma in the city of Malmö, Sweden. A prospective study

Scandinavian Journal of Gastroenterology
J H SimánC H Florén

Abstract

We have investigated the association between Helicobacter pylori and gastric carcinoma through a nested case-control study in a single city. From a cohort of 32,906 residents recruited from 1974 through 1992, 56 cases of gastric adenocarcinoma and 224 matched controls were selected. The mean interval between serum collection and diagnosis was 5.7 years. Frozen serum or plasma samples were analysed for IgG antibodies against H. pylori with an enzyme-linked immunosorbent assay. The overall seropositivity prevalence in gastric cancer cases was 82%, compared with 49% in controls, giving an odds ratio (OR) of 5.0 (95% confidence interval (CI), 2.2-11.5). Partial gastrectomy because of peptic ulcer 5 to 36 year before diagnosis of gastric cancer could be a confounding factor. With exclusion of 10 such cases, H. pylori seropositivity among cases was 78%, as compared with 50% in matched controls (OR, 3.9; 95% CI, 1.7-9.2). Tumours of the cardia were not associated with H. pylori (OR, 0.92; 95% CI, 0.23-3.7), which is in contrast to tumours of the fundus, corpus, and antrum, which were significantly associated (OR, 11.1; 95% CI, 2.4-71.8). This difference in location was significant (P < 0.01). There is a significant association between...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T NguyenS R Tannenbaum
Apr 1, 1992·Journal of Clinical Pathology·P SipponenK Seppälä
Apr 1, 1992·Gut·C Holcombe
Mar 4, 1992·Journal of the National Cancer Institute·D G HoelA J Swerdlow
Dec 4, 1991·Journal of the National Cancer Institute·N J TalleyM J Blaser
Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Oct 17, 1991·The New England Journal of Medicine·A NomuraM J Blaser
Jan 1, 1991·Journal of Clinical Pathology·R L SidebothamJ H Baron
Oct 15, 1990·International Journal of Cancer. Journal International Du Cancer·D FormanJ Chen
Feb 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H GnarpeS Mäkitalo
Feb 15, 1988·International Journal of Cancer. Journal International Du Cancer·D M ParkinC S Muir
Jan 1, 1980·Journal of Chronic Diseases·B S Pasternak, R E Shore
Jan 1, 1995·Japanese Journal of Cancer Research : Gann·H FukudaM Katoh
Jun 17, 1995·Lancet·E J KuipersS G Meuwissen
Jan 22, 1994·Lancet·D FormanJ Parsonnet
Jan 1, 1995·Cancer·R M Thomas, L H Sobin
Nov 11, 1993·International Journal of Cancer. Journal International Du Cancer·M J BlaserG I Pérez-Pérez
Sep 1, 1993·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·J EstevensF C Mira
Mar 1, 1993·The British Journal of Surgery·L E HanssonO Nyrén
May 1, 1993·Scandinavian Journal of Gastroenterology·E J KuipersS G Meuwissen
Jul 25, 1996·The New England Journal of Medicine·L E HanssonH O Adami
Sep 4, 1996·International Journal of Cancer. Journal International Du Cancer·P M WebbR K Ross
Jun 1, 1996·Scandinavian Journal of Gastroenterology·J ValleM Siurala
Aug 1, 1996·Postgraduate Medical Journal·P McCulloch
Mar 1, 1996·Scandinavian Journal of Gastroenterology·P SipponenM Siurala

❮ Previous
Next ❯

Citations

Dec 25, 2010·Cancer Causes & Control : CCC·Marlene Cavaleiro-PintoHenrique Barros
Feb 19, 2003·Journal of Clinical Epidemiology·Jon R Kelley, John M Duggan
Sep 5, 2001·The British Journal of Surgery·H M KocherJ P Ellul
Feb 7, 2001·Journal of the National Cancer Institute·P LimburgS Dawsey
Mar 6, 2008·Journal of Gastroenterology and Hepatology·Kwong Ming FockUNKNOWN Asia-Pacific Gastric Cancer Consensus Conference
Jul 1, 2008·Therapeutic Advances in Gastroenterology·Richard M Peek
Jan 15, 2014·PloS One·Caiyun XuanDelphine J Lee
May 4, 2013·Gastroenterology Clinics of North America·Catherine de MartelMartyn Plummer
Mar 29, 2001·São Paulo Medical Journal = Revista Paulista De Medicina·S K OgataA M Santos
Jul 11, 2009·The American Journal of the Medical Sciences·Irfan YavasogluSamet Kafkas
Mar 21, 2002·Nature Reviews. Cancer·Richard M Peek, Martin J Blaser
Jan 8, 2003·International Journal of Cancer. Journal International Du Cancer·Anna H WuDavid Forman
Aug 15, 2003·International Journal of Cancer. Journal International Du Cancer·Nuno Lunet, Henrique Barros
May 17, 2006·European Journal of Gastroenterology & Hepatology·Rickard EkesboKristina Sjölund
Nov 30, 2000·The American Journal of Gastroenterology·M J ChenS L Wu
Sep 14, 1999·The American Journal of Gastroenterology·G D EslickN J Talley
Apr 5, 2005·Nature Reviews. Microbiology·Alistair J Lax
Dec 20, 2005·The Journal of Pathology·Richard M Peek, Jean E Crabtree
Apr 5, 2007·British Journal of Cancer·K HemminkiJ Ji
Feb 9, 2005·Clinical and Diagnostic Laboratory Immunology·J Henrik SimánArne Forsgren
Oct 20, 2000·Luminescence : the Journal of Biological and Chemical Luminescence·T AbeY Saito
Jun 4, 2014·International Journal of Cancer. Journal International Du Cancer·Martyn PlummerCatherine de Martel
May 3, 2000·Journal of Physiology, Paris·F PakodiG Mózsik
May 21, 2010·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Dorthe JohansenBjörn Lindkvist

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.