Association between Helicobacter pylori infection and cirrhosis in patients with chronic hepatitis C virus

Digestive Diseases and Sciences
Dulciene Maria Magalhães QueirozHugo Tanno

Abstract

We evaluated, employing a logistic regression model, the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients (57 males; mean age, 52.9 years; range, 20-78 years) with chronic hepatitis C virus (HCV) from Rosario, Argentina. HCV was confirmed by ELISA and PCR. H. pylori status was determined by ELISA. Of the 106 patients evaluated, 47 (44.3%) had cirrhosis. A total of 70.2% (33/47) of cirrhotic patients and 47.5% (28/59) of noncirrhotic patients were H. pylori-positive. In univariate analyses, cirrhosis was associated with age (P = 0.016) and H. pylori-positive status (P = 0.019) but not with gender (P = 0.28) or length of infection (P = 0.35). In multivariate analysis, H. pylori infection (P = 0.037; OR = 2.42; 95% CI = 1.06-5.53) and age (P = 0.033; OR = 1.04; 95% CI = 1.00-1.07) of patients remained significant and independently associated with cirrhosis. In conclusion, our results demonstrate an association between H. pylori infection and cirrhosis in patients with hepatitis C virus.

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Citations

Dec 10, 2009·Future Microbiology·Quoc V TuGeorge L Mendz
Dec 20, 2007·Srpski arhiv za celokupno lekarstvo·Tamara AlempijevićSlobodan Krstić
Mar 20, 2008·World Journal of Gastroenterology : WJG·Shu-Jie ChenJian-Min Si
Mar 20, 2010·Journal of Global Infectious Diseases·Samir El-MasryMahmoud Lotfy
Aug 5, 2015·International Journal of Oncology·Junwei WangFeifei She
Jul 9, 2013·Clinics and Research in Hepatology and Gastroenterology·Bang-Li HuGuang-Ye Yang
May 11, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Saber A SakrRania A Sheir
Jun 21, 2012·Journal of Digestive Diseases·Huck-Joo Tan, Khean-Lee Goh
Feb 7, 2012·European Journal of Cell Biology·Emilie Le Roux-GoglinElisabeth Génot
Oct 23, 2010·Journal of Neuroimmunology·Jannis KountourasIakovos Tsiptsios
Mar 28, 2008·The Korean Journal of Internal Medicine·Dong Joon KimChoong Kee Park
Jan 6, 2016·World Journal of Hepatology·Elizabeth Ma Rabelo-GonçalvesJosé Mr Zeitune
Sep 4, 2015·World Journal of Hepatology·Marek WalugaRafał Kotulski
May 23, 2020·Clinical and Experimental Gastroenterology·Lina ElsalemOsama Aloudat
Mar 19, 2019·Gastroenterology Research and Practice·Mohamed A ElsebaeySherief Abd-Elsalam
Mar 17, 2010·Arquivos De Gastroenterologia·Rozangela Maria de Almeida Fernandes WyszomirskaCláudio Torres Miranda
Sep 1, 2018·World Journal of Gastroenterology : WJG·Kazuya OkushinKazuhiko Koike
Feb 24, 2018·Genomics, Proteomics & Bioinformatics·Changting MengQiang Tian

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