Association between Helicobacter pylori seropositivity and digestive tract cancers.

World Journal of Gastroenterology : WJG
I-Chen WuMing-Tsang Wu

Abstract

To explore the role of Helicobacter pylori (H pylori) infection on the risk of digestive tract cancers. In total, 199 oral squamous-cell carcinoma (SCC), 317 esophageal SCC, 196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of H pylori infection. Two hospital- and one community-based control groups were used for the comparisons. H pylori seropositivity was determined by an enzyme linked immunosorbent assay method against H pylori IgG. Presence of H pylori infection was significantly inversely associated with esophageal SCC [adjusted odds ratio (AOR): 0.315-0.472, all P-value < 0.05] but positively associated with gastric adenocarcinoma (both cardia and non-cardia) (AOR: 1.636-3.060, all P-value < 0.05) in comparison to the three control groups. Similar results were not found in cancers of the oral cavity and colon. Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma.

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Citations

Dec 23, 2011·The Pediatric Infectious Disease Journal·Haiying ChengMizu Jiang
Oct 10, 2013·World Journal of Gastroenterology : WJG·Fa-Jun XieWei-Min Mao
Apr 18, 2014·Indian Journal of Pathology & Microbiology·Guan Xiao YingWang Hong Tao
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Feb 8, 2020·Clinical and Translational Gastroenterology·Da Sol ChoiChan Hyuk Park
Dec 25, 2019·Gastroenterology Research and Practice·Huiqin GaoWensheng Pan
Jul 9, 2021·Digestive Diseases and Sciences·Ali SoroushJulian A Abrams

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