Association between hemoglobin A1c, carotid atherosclerosis, arterial stiffness, and peripheral arterial disease in Korean type 2 diabetic patients

Journal of Diabetes and Its Complications
Seong-Woo ChoiJin-Su Choi

Abstract

To evaluate the association between hemoglobin A(1c) (HbA(1c)), carotid atherosclerosis, arterial stiffness, and peripheral arterial disease (PAD) in Korean type 2 diabetic patients. A total of 370 type 2 diabetic patients registered with the public health center in Gokseng-gun, Korea, participated in this study. Following an overnight fast, venous blood was collected and analyzed by high-performance liquid chromatography. The carotid intima-media thickness (IMT), amount of carotid plaque, brachial ankle pulse wave velocity (baPWV), and ankle-brachial index (ABI) of each patient were also assessed. For categorical variables, we performed logistic regression after adjustment for other CVD risk factors. There was a significant association between HbA(1c) and carotid plaque [OR 2.66, 95% confidence interval (CI) 1.01 to 5.67 for the highest vs. the lowest tertile of HbA(1c)], and PAD (OR 3.75, 95% CI 1.30 to 10.81). For continuous variables, we performed analysis of covariance (ANCOVA) after adjustment for other covariates. The mean values of common carotid artery intima-media thickness (CCA-IMT) and baPWV were not significantly different according to the HbA(1c) tertiles. HbA(1c) was significantly associated with carotid plaque a...Continue Reading

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Citations

Oct 24, 2012·Journal of Korean Medical Science·Seong-Woo ChoiMin-Ho Shin
Oct 30, 2016·BMC Cardiovascular Disorders·Manuel A Gomez-MarcosUNKNOWN MARK Group
Oct 4, 2014·Frontiers in Aging Neuroscience·Alexander BirbrairOsvaldo Delbono
Oct 14, 2017·Chonnam Medical Journal·Mi Suk AnMin-Ho Shin
Dec 23, 2011·Clinical & Developmental Immunology·F PandolfiC Barone
Mar 10, 2020·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·I-Te Lee
Nov 18, 2011·Southern Medical Journal·Roger Everett KelleyGerald S Berenson

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