Association between high on-treatment platelet reactivity and occurrence of cerebral ischemic events in patients undergoing percutaneous coronary intervention

Thrombosis Research
A KomosaS Grajek

Abstract

Percutaneous coronary angioplasty (PCI) has become a routine treatment in symptomatic patients with coronary artery disease. The use of new generation drug eluting stents (DES) and dual antiplatelet therapy has significantly improved treatment outcomes and increased patients' safety by reducing the risk of stent thrombosis. The goal of this study was to assess whether high on treatment platelet reactivity (HTPR), despite clopidogrel treatment, measured with Multiplate Electrode Aggregometer (MEA) is associated with the risk of adverse ischemic cerebral events. Symptomatic patients with coronary artery disease admitted for coronary angiography and angioplasty (PCI) were consecutively enrolled in this study. 249 consecutive patients underwent coronary artery stenting for stable angina (n=215) or non-ST-elevation acute coronary syndrome (n=34). Inhibition of platelet aggregation was assessed by MEA. Genetic polymorphism of CYP2C19 was tested by HRM Real-Time PCR method in 150 patients. Patients with HTPR were more frequently diagnosed with ischemic stroke (p=0.0351, OR=16.818, 95% CI [1.464-193.23]) and other ischemic cerebral events (stroke or TIA, p=0.0339, OR=6.5, 95% CI [1.36-31.07]). Cumulative assessment of all ischemic and ...Continue Reading

References

Nov 8, 2003·Stroke; a Journal of Cerebral Circulation·Chelsea S Kidwell, Steven Warach
Dec 2, 2006·Thrombosis and Haemostasis·Orsolya TóthWolfgang Siess
Mar 10, 2009·The American Journal of Cardiology·Betti GiustiGian Franco Gensini
Jun 3, 2009·Circulation·Ana PenaGilles Montalescot
Jun 11, 2010·BMC Medical Genetics·Diogo G B SantosAlexandre C Pereira
Sep 11, 2010·Journal of the American College of Cardiology·Laurent BonelloUNKNOWN Working Group on High On-Treatment Platelet Reactivity
Feb 15, 2011·Current Vascular Pharmacology·Jayashree ShankerVijay V Kakkar
May 20, 2011·Thrombosis Research·Tong Yin, Toshiyuki Miyata
Dec 29, 2011·JAMA : the Journal of the American Medical Association·Michael V HolmesJuan P Casas
Jan 21, 2012·Journal of Thrombosis and Haemostasis : JTH·J M Siller-MatulaB Jilma
Jun 5, 2012·International Journal of Cardiology·Jolanta M Siller-MatulaGünter Christ
Aug 25, 2012·Platelets·Paul Harrison
Jul 26, 2013·Thrombosis and Haemostasis·Jolanta M Siller-Matula, Bernd Jilma
Oct 10, 2014·Expert Opinion on Pharmacotherapy·Udaya S TantryPaul A Gurbel

❮ Previous
Next ❯

Citations

Jul 2, 2016·British Journal of Clinical Pharmacology·Jolanta M Siller-MatulaIrene M Lang
Feb 17, 2017·European Heart Journal. Cardiovascular Pharmacotherapy·Max-Paul WinterJolanta M Siller-Matula
Dec 19, 2019·Frontiers in Cardiovascular Medicine·Małgorzata OstrowskaJolanta M Siller-Matula
Oct 10, 2020·The Pharmacogenomics Journal·Conti ValeriaFilippelli Amelia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.