Association between hippuric acid and left ventricular hypertrophy in maintenance hemodialysis patients

Clinica Chimica Acta; International Journal of Clinical Chemistry
Teng-Hung YuYau-Jiunn Lee

Abstract

Left ventricular hypertrophy (LVH) is one of the most common cardiac abnormalities in patients with end-stage renal disease. Hippuric acid (HA), a harmful uremic toxin, is known to be elevated in patients with uremia, and serum HA levels are associated with neurological symptoms, metabolic acidosis, and accelerated renal damage associated with chronic kidney disease. However, the pathophysiological role of HA in patients with uremia remains unclear. We investigated the association between serum HA levels and echocardiographic measurements in patients undergoing hemodialysis (HD) treatment. Eighty consecutive patients treated at a single HD center (44 males, 36 females; mean age 66 y, mean HD duration 6 y) were included in this study. Comprehensive echocardiography was performed after HD. Blood samples were obtained before HD. Pearson's correlation analysis revealed that serum HA levels were positively correlated with diastolic blood pressure, serum creatinine, left ventricular mass index, end diastolic interventricular septal thickness, left ventricular end-diastolic diameter, left ventricular end systolic diameter, end systolic left ventricular posterior wall thickness, and left atrium diameter, and negatively correlated with ...Continue Reading

Citations

Jun 15, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kiyotaka UchiyamaHiroshi Itoh
Jan 29, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yung-Chuan LuChao-Ping Wang
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kamil ŁuczykowskiBarbara Bojko
Aug 20, 2021·Ecotoxicology and Environmental Safety·Li ZhuYu Zhang

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