PMID: 8971109Dec 1, 1996Paper

Association between HIV distal symmetric polyneuropathy and Mycobacterium avium complex infection

Journal of Neurology, Neurosurgery, and Psychiatry
G R NortonB J Brew

Abstract

Pronounced infiltration of activated macrophages occurs in the peripheral nerves of patients with HIV distal symmetric polyneuropathy (DSPN). Mycobacterium avium complex (MAC) is a common facultative intracellular parasite of the macrophage in advanced HIV disease and may induce macrophage activation. Whether MAC disease is associated with DSPN was examined prospectively. One hundred and fifty consecutive patients with HIV infection were assessed for the probability of DSPN. Blood cultures for MAC were performed, independently of neurological assessment, as part of the investigation of unexplained fever, anaemia, weight loss, or, less commonly, diarrhoea. There were 20 patients with possible, 14 with probable, and 22 with definite HIV DSPN. Blood cultures for MAC were performed on 80 patients, of whom 39 were positive and 41 negative. The test for trend, when corrected for CD4 count, disclosed a significant association (P = 0.01). There was no statistically significant association between DSPN and cytomegalovirus (CMV) disease. Coinfection of the macrophage by MAC may further activate the HIV infected macrophage thereby accelerating the elaboration of neural toxins or MAC infection of the macrophage itself may lead to the produ...Continue Reading

References

Nov 1, 1985·Annals of Internal Medicine·D ArmstrongT E Kiehn
Apr 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·G N FullerR J Guiloff

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Citations

Nov 2, 2005·Neurotoxicity Research·P B Tran, R J Miller
Oct 15, 2005·Nature Reviews. Drug Discovery·Fletcher A WhiteRichard J Miller
Jan 21, 2004·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Judith Gale
Nov 30, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Robert S Root-Bernstein
Jul 6, 2004·Arquivos de neuro-psiquiatria·Claudia ZanettiAlberto A Gabbai

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