Association Between HIV Symptom Burden and Inflammatory Cytokines: An Analysis by Sex and Menopause Stage.

Journal of Women's Health
Rebecca SchnallNancy Reame

Abstract

Introduction: There is a growing body of knowledge characterizing the menopause experience in those with HIV. The primary goal of this study was to assess inflammatory cytokine associations with symptoms and sex-specific differences, and the secondary focus was to assess differences among women by menopause status. Materials and Methods: One hundred persons living with HIV (PLWH) (25 men and 75 women recruited by menopause stage) completed a blood draw for hormones and cytokines and study questions on demographics, height and weight, reproductive health status, HIV symptoms, PROMIS-29 measures, and most recent viral load; study visits were synchronized to the early follicular phase in women with regular cycles. Results: In both sexes, the most burdensome HIV symptoms were muscle aches/joint pain, difficulty falling asleep, fatigue, and neuropathy. Three of the five symptoms where burden scores differed by menopause stage were related to pain with highest scores in the premenopause group; the postmenopause group also demonstrated a similar burden for muscle aches/joint pain while scores for men and perimenopause women were lowest. Pain intensity scores on the PROMIS-29 also varied significantly by groups. After controlling for s...Continue Reading

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Citations

May 3, 2020·Biology of Sex Differences·Letizia SantinelliGabriella d'Ettorre
Jan 16, 2021·The Journal of the Association of Nurses in AIDS Care : JANAC·Youngran YangFrances Marcus Lewis
Jan 16, 2021·The Journal of the Association of Nurses in AIDS Care : JANAC·Annie NguyenMarcia McDonnell Holstad
Jun 29, 2021·Frontiers in Psychology·Maria José Fuster-RuizdeApodacaJeffrey V Lazarus
Jul 9, 2021·Current Pain and Headache Reports·Kaitlyn E EganMaxim S Eckmann

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Methods Mentioned

BETA
hormone
hysterectomy
blood draw
ELISA

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