Association between HLA and Stevens-Johnson syndrome induced by carbamazepine in Southern Han Chinese: genetic markers besides B*1502?

Basic & Clinical Pharmacology & Toxicology
Yi-Wu ShiWei-Ping Liao

Abstract

Previous studies have demonstrated a strong association between carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (CBZ-induced SJS/TEN) and HLA-B*1502 in Chinese, and HLA-A*3101 but not HLA-B*1502 in Caucasians and Japanese. Cases with CBZ-induced SJS/TEN negative for HLA-B*1502 were reported recently in Southeast Asia. Negative correlations between CBZ-induced SJS/TEN and B*0702 or B*4001 have also been reported, suggesting a possible protective role. Here, we genotyped HLA-B and HLA-A in 18 cases with CBZ-induced SJS/TEN, in comparison with CBZ-tolerant and normal controls in Southern Han Chinese. A strong association between HLA-B*1502 and CBZ-induced SJS/TEN was found, with 72.2% sensitivity and 87.1% specificity. However, we also found five patients with SJS (5/18, 27.78%) who were negative for HLA-B*1502. HLA-A*2402 was present in nine of 16 cases with SJS (56.25%, including three of five cases negative for HLA-B*1502), which was significantly more frequent than that of CBZ-tolerant controls or the general southern population. Only one case with SJS carried HLA-A*3101. No statistical difference in the mean age, sex ratio and CBZ usage was found between the CBZ-induced SJS/TEN group and the CBZ-...Continue Reading

References

Jun 1, 1994·The Journal of Investigative Dermatology·J C Roujeau
Apr 2, 2004·Nature·Wen-Hung ChungYuan-Tsong Chen
Mar 16, 2006·Pharmacogenetics and Genomics·Shuen-Iu HungYuan-Tsong Chen
Sep 20, 2006·Pharmacogenomics·Ana AlfirevicMunir Pirmohamed
Sep 9, 2008·Seminars in Neurology·Rafael Toledano, Antonio Gil-Nagel
Aug 12, 2009·Pharmacogenetics and Genomics·Gbenga R KazeemElizabeth Foot
Nov 17, 2009·Indian Journal of Dermatology, Venereology and Leprology·Timir Y MehtaRamesh K Goyal
Dec 1, 2009·American Journal of Human Genetics·Jieming ChenJianjun Liu
Jun 12, 2010·Expert Opinion on Pharmacotherapy·Ming Ta Michael LeeYuan-Tsong Chen
Feb 11, 2011·Basic & Clinical Pharmacology & Toxicology·Yi-Wu ShiWei-Ping Liao
Mar 25, 2011·The New England Journal of Medicine·Mark McCormackMunir Pirmohamed
Aug 19, 2011·The New England Journal of Medicine·Wei-Ping LiaoFu-Li Min
Aug 19, 2011·The New England Journal of Medicine·Elizabeth J Phillips, Simon A Mallal
Sep 20, 2011·The Journal of Allergy and Clinical Immunology·Tai-Ming KoShuen-Iu Hung
Oct 4, 2011·Chemical & Pharmaceutical Bulletin·M D Iqbal MahmoodTyuji Hoshino

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Citations

Feb 6, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Dan SunHui-Hui Xiang
Jul 16, 2014·Immunology and Allergy Clinics of North America·Young-Min YeHae-Sim Park
Oct 30, 2016·Current Opinion in Immunology·Patricia T IllingAnthony W Purcell
Jan 17, 2017·International Journal of Immunogenetics·G S GhattaorayaA Alfirevic
Mar 22, 2019·HLA : Immune Response Genetics·Kerry A MullanNicole A Mifsud
Mar 21, 2017·Drug Metabolism and Personalized Therapy·Ingrid Fricke-GalindoMarisol López-López
Jul 12, 2017·Immunogenetics·Patricia T IllingJames McCluskey
May 9, 2019·Clinical Pharmacology and Therapeutics·Paola NicolettiMunir Pirmohamed
Jan 4, 2020·Allergy·Abderrahim OussalahUNKNOWN Task Force “Genetic predictors of drug hypersensitivity” of the European Network on Drug Allergy (ENDA), European Academy of
Jun 22, 2021·Expert Opinion on Drug Metabolism & Toxicology·Thawinee JantararoungtongChonlaphat Sukasem
Apr 14, 2021·International Journal of Dermatology·Ting-Jung HsuKwei-Lan Liu
Sep 24, 2021·International Journal of Dermatology·Christina S M WongJanette S Y Kwok
Jun 10, 2021·Clinical and Translational Science·Chiara JeizinerHenriette E Meyer Zu Schwabedissen

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