PMID: 6137649Oct 8, 1983

Association between HLA-B antigens and acute graft-versus-host disease

Lancet
R StorbE D Thomas

Abstract

130 patients with severe aplastic anaemia, conditioned with high-dose cyclophosphamide, showed sustained engraftment of marrow from HLA-identical siblings. Most patients (55%) had no acute graft-versus-host disease (GVHD), 11% had transient grade I, and 34% had moderate to severe (grades II-IV) acute GVHD. The relation between the donors' (and the patients') HLA antigens and the incidence of grades I-IV acute GVHD was explored. There was no association with HLA-A antigens, but a significant correlation with HLA-B antigens. Patients with HLA-B18 had an estimated acute GVHD incidence nearly three times that of other patients, whereas the incidence in the presence of HLA-B8 or HLA-Bw35 was estimated to be about half that in the absence of these alleles.

Citations

Jul 27, 2001·British Journal of Haematology·R E ClarkChronic Leukaemia Working Party of the European Group of Blood and Bone Marrow Transplantation
Aug 1, 1997·Tissue Antigens·P J MartinJ A Hansen
Dec 1, 1985·Immunological Reviews·R Storb, E D Thomas
Dec 1, 1985·Immunological Reviews
Sep 12, 2012·São Paulo Medical Journal = Revista Paulista De Medicina·Daniela Máira CardozoJeane Eliete Laguila Visentainer
Nov 30, 1999·Hematology/oncology Clinics of North America·Mary E D FlowersK M Sullivan
Jul 1, 1987·Statistics in Medicine·D O Dixon, G W Divine
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Dec 1, 1985·Immunological Reviews·R P Gale

Related Concepts

Acute Disease
Alleles
Hypoplastic Anemia
Graft-vs-Host Disease
HLA Antigens
HLA-B Antigens
Bone Marrow Cell Transplantation

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