PMID: 6137649Oct 8, 1983

Association between HLA-B antigens and acute graft-versus-host disease

R StorbE D Thomas


130 patients with severe aplastic anaemia, conditioned with high-dose cyclophosphamide, showed sustained engraftment of marrow from HLA-identical siblings. Most patients (55%) had no acute graft-versus-host disease (GVHD), 11% had transient grade I, and 34% had moderate to severe (grades II-IV) acute GVHD. The relation between the donors' (and the patients') HLA antigens and the incidence of grades I-IV acute GVHD was explored. There was no association with HLA-A antigens, but a significant correlation with HLA-B antigens. Patients with HLA-B18 had an estimated acute GVHD incidence nearly three times that of other patients, whereas the incidence in the presence of HLA-B8 or HLA-Bw35 was estimated to be about half that in the absence of these alleles.


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Jan 1, 1986·International Journal of Cell Cloning·K M Sullivan
Jan 1, 1990·Springer Seminars in Immunopathology·G J Cox, G B McDonald
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Dec 25, 2004·European Journal of Gastroenterology & Hepatology·Manal H El-SayedHossam K Mahmoud
Dec 1, 1985·Immunological Reviews·R P Gale

Related Concepts

Acute Disease
Hypoplastic Anemia
Graft-vs-Host Disease
HLA Antigens
HLA-B Antigens
Bone Marrow Cell Transplantation

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