Association between HLA-DP Gene Polymorphisms and Cervical Cancer Risk: A Meta-Analysis

BioMed Research International
Lin ChengPeiyuan Xia

Abstract

Objective. We aimed to derive a more precise estimation of the associations between human leukocyte antigens DP (HLA-DP) gene polymorphisms and cervical cancer risk by meta-analysis. Methods. PubMed, EMBASE, ScienceDirect, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases were systematically searched to identify studies investigating the relationship between HLA-DP gene polymorphisms and cervical cancer. The associations between them were evaluated by pooled OR and 95% CI. Results. A total of 11 studies including 5008 cases and 9322 controls with 11 HLA-DP alleles were included in the current meta-analysis. Results. The results showed that HLA-DPB1⁎03:01 was significantly associated with an increased risk of cervical cancer (OR=1.252, 95%CI: 1.116-1.403, Pz=0.001), while HLA-DPB1⁎04:02 and HLA-DP rs3117027 G allele were significantly associated with a decreased risk of cervical cancer (OR=0.744, 95%CI: 0.652-0.848, Pz=0.001; OR=0.790, 95%CI: 0.745-0.837, Pz=0.001), and HLA-DP rs9277535 G allele was significantly associated with a decreased risk of cervical cancer in Asia (OR=0.802, 95%CI: 0.753-0.855, Pz=0.001). Subgroup analyses based on race system showed that HLA-DPB1⁎13:01 was significa...Continue Reading

References

Nov 25, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·N Muñoz
Nov 26, 2002·Virus Research·Allan Hildesheim, Sophia S Wang
Dec 2, 2004·Nature Reviews. Genetics·Roger HortonStephan Beck
Oct 13, 2005·Vaccine·Margaret Stanley
Nov 26, 2008·Cancer Genetics and Cytogenetics·Jinxiao LiangZhongqiu Lin
Apr 21, 2009·Future Oncology·Patrícia Savio de Araujo SouzaPaulo Cesar Maciag
Sep 25, 2009·Digestive Diseases and Sciences·Jing WangQian He
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
May 24, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mark SchiffmanRobert D Burk
Aug 28, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Francesco BroccoloLuca Ceccherini-Nelli
Mar 14, 2013·Journal of the National Cancer Institute·Dan ChenUlf Gyllensten
Feb 20, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·X ZhangZ Wang
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jun 3, 2015·Cancer Immunology, Immunotherapy : CII·Yuh-Cheng YangYann-Jinn Lee
Jun 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiangjun SunYutong Wang
Dec 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Meiqun JiaNi Li
Mar 11, 2017·Journal of Immunology Research·Akash M MehtaEkaterina S Jordanova

❮ Previous
Next ❯

Citations

Nov 20, 2019·HLA : Immune Response Genetics·L Burmistrova AlexandraA Suslova Tatiana
May 1, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter van BalenJ H Frederik Falkenburg
Jul 31, 2021·Immunology Letters·Constantina A SarriZissis Mamuris
Oct 15, 2020·The International Journal of Biological Markers·Guoqiang Zhang, Maohe Jin

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.