Association between HLA-DRB1 polymorphisms and pemphigus vulgaris: a meta-analysis.

The British Journal of Dermatology
L YanK Zeng

Abstract

Several studies have reported that HLA-DRB1 may be correlated with pemphigus vulgaris (PV), but most have been based on small samples and the results remain inconsistent and unclear. To investigate the correlation between DRB1 and PV by a meta-analysis of case-control/nonfamily studies. PubMed, Wiley Online Library, ScienceDirect, Google Scholar, Cochrane Library, Chinese National Knowledge Infrastructure and Wanfang databases were searched for studies including: (i) 'pemphigus'; and (ii) 'human leukocyte antigen', 'HLA', 'major histocompatibility complex', 'MHC' or 'DRB1'. Eighteen selected studies were used in meta-analyses to evaluate DRB1 alleles and phenotypes by calculating the respective odds ratios (ORs) and 95% confidence intervals (CIs). Stratified meta-analyses and meta-regression analysis were also conducted. The frequencies of three genotypes (allele and phenotype, respectively) were significantly increased in PV: DRB1*04 [P-value for comparability (Pc) < 0.00001, OR 3.61, 95% CI 2.28-5.71; Pc = 0.0002, OR 4.14, 95% CI 1.98-8.65], DRB1*08 (Pc = 0.03, OR 2.25, 95% CI 1.07-4.70; Pc = 0.0003, OR 2.46, 95% CI 1.51-4.01) and DRB1*14 (Pc < 0.00001, OR 6.47, 95% CI 4.52-9.26; Pc < 0.00001, OR 9.68, 95% CI 4.47-20.98). Thr...Continue Reading

References

Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A R AhmedE J Yunis
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A R AhmedC A Alper
May 1, 1981·Controlled Clinical Trials·T C ChalmersA Ambroz
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Nov 5, 1997·The Journal of Investigative Dermatology·S MiyagawaT Shirai
May 16, 1998·BMJ : British Medical Journal·T V Perneger
Nov 5, 1998·Tissue Antigens·M F González-EscribanoA Núñez-Roldán
Jan 5, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·C W LeeJ J Hwang
Jul 27, 1999·The Journal of Investigative Dermatology·M L LombardiC Manzo
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian VeldmanMichael Hertl
Mar 21, 2003·The New England Journal of Medicine·Esteban González BurchardNeil Risch
Nov 25, 2003·The British Journal of Dermatology·K E HarmanUNKNOWN British Association of Dermatologists
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian VeldmanMichael Hertl
Aug 18, 2004·Trends in Genetics : TIG·Marcus R Munafò, Jonathan Flint
Nov 30, 2004·Dental Clinics of North America·Dominik A Ettlin
Dec 29, 2004·Clinical Biomechanics·L LeonardA W Miles
May 5, 2005·Journal of Autoimmunity·François TronMourad Ben Ayed
Jul 5, 2005·Lancet·Jean-Claude Bystryn, Jennifer L Rudolph
Oct 27, 2006·The New England Journal of Medicine·John R Stanley, Masayuki Amagai
Nov 27, 2007·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·C BrickM Essakalli
Aug 19, 2008·Autoimmunity Reviews·Lior SagiYehuda Shoenfeld
Sep 10, 2008·Journal of Clinical Immunology·Sheida ShamsBehrouz Nikbin
Oct 23, 2009·The Journal of Investigative Dermatology·Monika SahaRichard W Groves
Jun 3, 2011·World Journal of Gastroenterology : WJG·Yong-Ning XinShi-Ying Xuan
Jun 29, 2011·Journal of Cardiovascular Medicine·Jinlong DengXiaoping Li

❮ Previous
Next ❯

Citations

Nov 26, 2015·Seminars in Immunopathology·Giovanni Di ZenzoLuca Borradori
Mar 8, 2014·International Journal of Dermatology·Danka SvecovaMilan Buc
Apr 10, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Huimin YangXiaoli Yang
Jan 7, 2015·The Journal of Dermatology·Meng PanRenchao Xu
Feb 26, 2016·Annual Review of Pathology·Christoph M Hammers, John R Stanley
Aug 19, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Keqing YaoLianqing Li
Oct 1, 2016·BioMed Research International·Zhangjun LiShengxiang Xiao
Feb 16, 2017·International Journal of Dermatology·Julio M GilIvan D Miziara
Oct 27, 2018·The British Journal of Dermatology·M Grau-PérezG Carretero-Hernández
Sep 20, 2018·The British Journal of Dermatology·S Y ZhangW Li
Aug 30, 2018·Frontiers in Medicine·Dan VodoEli Sprecher
Aug 30, 2020·American Journal of Clinical Dermatology·Emily M Altman
Jan 18, 2014·Experimental Dermatology·Kyle T AmberMichael Hertl
May 12, 2017·Nature Reviews. Disease Primers·Michael KasperkiewiczMasayuki Amagai
Nov 8, 2017·Archives of Dermatological Research·Soheil Tavakolpour
Aug 21, 2019·Frontiers in Immunology·Tianyu CaoGang Wang
Jan 10, 2018·Clinical Reviews in Allergy & Immunology·Robert PollmannMichael Hertl
Jan 9, 2021·International Immunopharmacology·Forugh GhaediMaryam Daneshpazhooh
Jan 8, 2021·International Journal of Dermatology·Elizabeth SchoenbergBahar Dasgeb
Sep 10, 2019·Lancet·Enno SchmidtPascal Joly
Mar 28, 2018·Indian Journal of Dermatology, Venereology and Leprology·Anuradha PriyadarshiniVisalakshi Jayaseelan
Apr 11, 2020·The Journal of Allergy and Clinical Immunology·Shohei EgamiMasayuki Amagai
Aug 12, 2021·Indian Journal of Dermatology, Venereology and Leprology·Sanjeev HandaDipankar De
Aug 27, 2021·Frontiers in Medicine·Thomas Schmitt, Jens Waschke
Sep 16, 2021·Wiener medizinische Wochenschrift·Peter MikoschEva Trifina-Mikosch
Oct 12, 2021·Experimental and Therapeutic Medicine·Victor-Vlad CostanMihaela Paula Toader

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

SE
Review Manager
STATA
RevMan

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.