Abstract
Several studies have reported that HLA-DRB1 may be correlated with pemphigus vulgaris (PV), but most have been based on small samples and the results remain inconsistent and unclear. To investigate the correlation between DRB1 and PV by a meta-analysis of case-control/nonfamily studies. PubMed, Wiley Online Library, ScienceDirect, Google Scholar, Cochrane Library, Chinese National Knowledge Infrastructure and Wanfang databases were searched for studies including: (i) 'pemphigus'; and (ii) 'human leukocyte antigen', 'HLA', 'major histocompatibility complex', 'MHC' or 'DRB1'. Eighteen selected studies were used in meta-analyses to evaluate DRB1 alleles and phenotypes by calculating the respective odds ratios (ORs) and 95% confidence intervals (CIs). Stratified meta-analyses and meta-regression analysis were also conducted. The frequencies of three genotypes (allele and phenotype, respectively) were significantly increased in PV: DRB1*04 [P-value for comparability (Pc) < 0.00001, OR 3.61, 95% CI 2.28-5.71; Pc = 0.0002, OR 4.14, 95% CI 1.98-8.65], DRB1*08 (Pc = 0.03, OR 2.25, 95% CI 1.07-4.70; Pc = 0.0003, OR 2.46, 95% CI 1.51-4.01) and DRB1*14 (Pc < 0.00001, OR 6.47, 95% CI 4.52-9.26; Pc < 0.00001, OR 9.68, 95% CI 4.47-20.98). Thr...Continue Reading
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