Association between human papillomavirus type and clonal status of cervical squamous intraepithelial lesions

Journal of the National Cancer Institute
T W ParkT C Wright

Abstract

Lesions that are histologically classified as precursors of cervical cancer, which are often referred to as squamous intraepithelial lesions (SILs), represent a heterogeneous clinical entity that can be associated with many different types of human papillomaviruses (HPVs) and have a variable biologic behavior. Approximately one half of low-grade SILs behave as non-neoplastic, productive viral lesions that frequently regress spontaneously, whereas the other half behave as neoplasms and either persist or progress to a histologically higher grade lesion. Identification of biomarkers that reliably differentiate those low-grade SILs with the properties of a non-neoplastic viral infection from those with the properties of neoplasia would provide a more rational basis for decisions about disease management. Since monoclonality is a hallmark of neoplasia irrespective or organ site, clonal status might represent one such biomarker. To better understand the pathobiology of SILs, we analyzed the clonality of low-grade and high-grade SILs and compared their clonal status with their associated HPV types. One hundred forty formalin-fixed, paraffin-embedded cervical biospy and loop electrosurgical specimens, originally diagnosed as SILs, were...Continue Reading

Citations

May 1, 1997·Cancer Genetics and Cytogenetics·N B Atkin
Jun 20, 1998·Sexually Transmitted Infections·S A Southern, C S Herrington
Jul 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cornelia L TrimbleDrew Pardoll
Jun 17, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alvaro P PintoEdmund S Cibas
Jan 22, 2015·The Journal of Pathology·Ian J Groves, Nicholas Coleman
Mar 18, 2000·The Journal of Dermatology·T Ishiji
Mar 16, 2000·Journal of the National Cancer Institute·R HerreroM Schiffman
Nov 14, 1997·International Journal of Cancer. Journal International Du Cancer·T EnomotoK R Shroyer
Dec 8, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·G L Mutter
Apr 11, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S RiethdorfT W Park
May 3, 2002·Cytopathology : Official Journal of the British Society for Clinical Cytology·J H F Smith
Sep 5, 2002·The Journal of Pathology·Arno KuijperPaul J van Diest
Apr 7, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Takashi MiyatakeTakayuki Enomoto
Apr 30, 2005·Cytopathology : Official Journal of the British Society for Clinical Cytology·M S Desai, Heather A Cubie
Jul 28, 2007·International Journal of Cancer. Journal International Du Cancer·Jenny BriolatChristine Clavel
Oct 6, 2007·Journal of Lower Genital Tract Disease·Thomas C WrightUNKNOWN 2006 American Society for Colposcopy and Cervical Pathology-sponsored Consensus Conference
Dec 14, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark F EvansKumarasen Cooper
Apr 13, 2000·International Journal of Experimental Pathology·S B GarciaN A Wright
Nov 1, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Thomas C Wright
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kaiyo TakuboTomio Arai

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