Association between hyperglycemia and retinopathy of prematurity: a systemic review and meta-analysis

Scientific Reports
Sunny C L AuJason C S Yam

Abstract

As the role of hyperglycemia in the development of retinopathy of prematurity (ROP) has not been well established, a meta-analysis of the association between hyperglycemia and ROP was conducted. Studies were identified through literature search in MEDLINE and EMBASE up to June 20, 2014 with keywords related to "hyperglycaemia" and "ROP". Nine eligible studies involving 1939 neonates with 509 cases of ROP were included. Unadjusted analyses showed that hyperglycemia was significantly associated with ROP (Odds ratio [OR] = 4.16, P<0.0001). Comparing with the control, subjects in the ROP group had a significantly longer duration of hyperglycemia (Standardized mean difference [SMD] = 1.21, P< 0.0001), and higher mean glucose level. (SMD = 0.88, P = 0.0004) However, when combining the adjusted OR (after adjustment for birth weight, gestational age and other factors) provided from individual studies, only borderline significant association were observed on duration of hyperglycemia with ROP (adjusted OR 1.08, P = 0.03); and no significant association on mean glucose level with ROP (adjusted OR = 1.08, P = 0.15). Hence, hyperglycemia cannot be definitely considered as a risk factor for ROP, and further studies should adjust for potenti...Continue Reading

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Citations

May 8, 2016·Biochimica Et Biophysica Acta·Zhongjie FuLois E H Smith
Dec 22, 2016·Clinical & Experimental Ophthalmology·Zhongjie FuAmy Cy Lo
Jun 4, 2017·The British Journal of Ophthalmology·Carina SlidsborgMorten de la Cour
Apr 11, 2018·The British Journal of Ophthalmology·Cheuk-Ling YimJason C S Yam
Nov 29, 2017·EMBO Molecular Medicine·Zhongjie FuLois Eh Smith
Jun 20, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Tammy Z Movsas, Arivalagan Muthusamy
Feb 2, 2020·NeoReviews·Sara Ramel, Raghavendra Rao
Sep 25, 2017·Physiological Research·N LenhartovaA Calkovska
Dec 12, 2020·PLoS Medicine·Elsa Kermorvant-DucheminJean-Christophe Rozé
Apr 22, 2018·Survey of Ophthalmology·Sang Jin KimMichael F Chiang
Jun 12, 2021·European Journal of Pediatrics·Chunyan LeiMeixia Zhang
Jul 15, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tahereh BahmaniSalman Daliri
Aug 1, 2021·Archives of Disease in Childhood. Fetal and Neonatal Edition·Chandra Prakash RathSanjay Patole
Jun 4, 2021·Canadian Journal of Physiology and Pharmacology·Juan-Juan WangDing-Ding Wang

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