Association between hyperglycemia, heart failure and mortality in stroke patients

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
T DziedzicA Szczudlik

Abstract

Acute hyperglycemia predicts increased mortality after stroke. The aim of our study was to determine if acute stroke patients with hyperglycemia suffer from increased rate of in-hospital adverse events which could influence survival such as pneumonia, heart failure and myocardial infarction. In a retrospective study with prospective follow-up, 689 patients with first-ever ischaemic stroke and high frequency of cardiovascular diseases were eligible. Follow-up period was 1-7 years (14 308 person-months). The frequency of in-hospital heart failure and nosocomial pneumonia was the highest in patients without pre-hospital diagnosis of diabetes mellitus and with fasting glucose >or=7 mmol/l (50% and 20.2%, respectively) and the lowest in patients without pre-hospital diagnosis of diabetes and fasting glucose <or=6.1 mmol/l (12.3% and 8.1%). On multivariate analysis fasting glucose was significantly associated with risk of in-hospital heart failure (OR: 1.12, 95% CI: 1.01-1.23), but not with pneumonia. Glucose level was an independent predictor of mortality only when statistical model did not include heart failure as a variable. In stroke patients with hyperglycemia increased rate of heart failure could be responsible for higher morta...Continue Reading

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Citations

Apr 1, 2011·Journal of the American Medical Directors Association·Claar D van der Maarel-WierinkCees de Baat
Feb 27, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Marcus M SeldinAldons J Lusis
Mar 24, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Rudruidee KarnchanasornKen C Chiu

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