Association between hyperinsulinaemia and laminitis severity at the time of pituitary pars intermedia dysfunction diagnosis

Equine Veterinary Journal
E M TadrosH C Schott

Abstract

Hyperinsulinaemia is the suspected component of insulin dysregulation having the strongest association with laminitis and occurs variably in equids with pituitary pars intermedia dysfunction (PPID). We hypothesised that magnitude of hyperinsulinaemia correlates with laminitis severity in PPID-affected equids. Furthermore, we hypothesised that owners can be unaware of chronic endocrinopathic laminitis. Cross-sectional study. Serum insulin concentrations, owner-reported laminitis history and radiographic evidence of laminitis were determined in 38 client-owned horses and ponies with confirmed PPID. Laminitis severity was classified into four categories (normal [nonlaminitic], mild, moderate or severe laminitis) based on degree of distal phalangeal rotation. Animals were also categorised as normoinsulinaemic (<20 μU/ml), mildly hyperinsulinaemic (20-50 μU/ml) and severely hyperinsulinaemic (>50 μU/ml). One-way ANOVA, t tests and Fisher's exact tests were performed. While owners reported laminitis in 37% of animals, 76% were laminitic based on study criteria (P = 0.01). Owners reported laminitis more frequently in hyperinsulinaemic vs. normoinsulinaemic animals; recognition increased with severity of hyperinsulinaemia (P = 0.03). M...Continue Reading

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Citations

Apr 12, 2019·Journal of Veterinary Internal Medicine·Melody A de LaatJames M McGree
Oct 17, 2019·Journal of Veterinary Internal Medicine·Dakota H LeschkeFrançois-René Bertin
Jun 26, 2020·Journal of Veterinary Internal Medicine·Simon M StokesAndrew W van Eps
Jan 31, 2019·Journal of Veterinary Internal Medicine·Melody A de LaatDania B Reiche
Mar 12, 2021·Journal of Veterinary Internal Medicine·Simon M StokesAndrew W van Eps
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Gemma R HicksFrançois-René Bertin

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