Association between IL-21 polymorphism and systemic lupus erythematosus: a meta-analysis

Genetics and Molecular Research : GMR
J H QiG Nie

Abstract

Several case-control studies have been conducted to investigate the association between Interleukin-21 (IL-21) polymorphisms and systemic lupus erythematosus (SLE) susceptibility, and most of the studies focused on IL-21 rs907715 and rs2221903 polymorphisms. Given the inconsistent results from these studies, the present meta-analysis aimed to obtain a more precise estimate of the association between IL-21 rs907715 and rs2221903 polymorphisms and SLE. Studies regarding these specific polymorphisms and SLE were retrieved from PubMed, Embase, Web of Science, CNKI, and CBM. Data were extracted and meta-analysis was performed using the STATA 12.0 software. For the IL-21 rs907715 polymorphism, seven sets of comparisons involving 7977 SLE cases and 8097 healthy controls were considered. Results showed that there were significant differences in the IL-21 rs907715 genotype distribution between SLE patients and healthy controls in the comparisons of all genetic models. Upon stratified analysis by ethnicity, a similar result was found in the Caucasian and African-American population. For the IL-21 rs2221903 polymorphism, seven sets of comparisons involving 7990 SLE cases and 8098 healthy controls were considered. Results showed that there...Continue Reading

Citations

Aug 9, 2016·Rheumatology·Noémie GensousPatrick Blanco
Dec 26, 2016·Rheumatology·Cristina ArriensChandra Mohan
Mar 25, 2020·World Journal of Gastrointestinal Oncology·Xiao-Qin WangMing-Xu Wang
Jan 18, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Chi-Chen HongChristine B Ambrosone
Jul 21, 2020·Clinical and Experimental Pediatrics·Seoung Wan NamAndreas Kronbichler

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