Association Between Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography Imaging and Adverse Events in Patients With Autoimmune Rheumatic Disease.

Circulation. Cardiovascular Imaging
Attila FeherMonique Hinchcliff

Abstract

Coronary microvascular dysfunction has been described in patients with autoimmune rheumatic disease (ARD). However, it is unknown whether positron emission tomography (PET)-derived myocardial flow reserve (MFR) can predict adverse events in this population. Patients with ARD without coronary artery disease who underwent dynamic rest-stress 82Rubidium PET were retrospectively studied and compared with patients without ARD matched for age, sex, and comorbidities. The association between MFR and a composite end point of mortality or myocardial infarction or heart failure admission was evaluated with time to event and Cox-regression analyses. In 101 patients with ARD (88% female, age: 62±10 years), when compared with matched patients without ARD (n=101), global MFR was significantly reduced (median: 1.68 [interquartile range: 1.34-2.05] versus 1.86 [interquartile range: 1.58-2.28]) and reduced MFR (<1.5) was more frequent (40% versus 22%). MFR did not differ among subtypes of ARDs. In survival analysis, patients with ARD and low MFR (MFR<1.5) had decreased event-free survival for the combined end point, when compared with patients with and without ARD and normal MFR (MFR>1.5) and when compared with patients without ARD and low MFR,...Continue Reading

References

Aug 1, 1992·The American Journal of Medicine·P H DesseinA E Stanwix
Jan 22, 2004·Rheumatology·A SulliF Indiveri
Dec 21, 2005·Rheumatology International· ShalimarRavindra Mohan Pandey
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Jan 15, 2011·JACC. Cardiovascular Imaging·Mariko L IshimoriC Noel Bairey Merz
Sep 17, 2015·Inflammation & Allergy Drug Targets·Sophie MavrogeniEfthymios Stavropoulos
Sep 11, 2016·Heart·Chang H KimGuilherme H Oliveira
Mar 22, 2021·JACC. Cardiovascular Imaging·Brittany N WeberMarcelo F Di Carli

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