Association between implementation of a code stroke system and poststroke epilepsy

Neurology
Ziyi ChenPatrick Kwan

Abstract

We aimed to investigate the effect of a code stroke system on the development of poststroke epilepsy. We retrospectively analyzed consecutive patients treated with IV thrombolysis under or outside the code stroke system between 2003 and 2012. Patients were followed up for at least 2 years or until death. Factors with p < 0.1 in univariate comparisons were selected for multivariable logistic and Cox regression. A total of 409 patients met the eligibility criteria. Their median age at stroke onset was 75 years (interquartile range 64-83 years); 220 (53.8%) were male. The median follow-up duration was 1,074 days (interquartile range 119-1,671 days). Thirty-two patients (7.8%) had poststroke seizures during follow-up, comprising 7 (1.7%) with acute symptomatic seizures and 25 (6.1%) with late-onset seizures. Twenty-six patients (6.4%) fulfilled the definition of poststroke epilepsy. Three hundred eighteen patients (77.8%) were treated with the code stroke system while 91 (22.2%) were not. After adjustment for age and stroke etiology, use of the code stroke system was associated with decreased odds of poststroke epilepsy (odds ratio = 0.36, 95% confidence interval 0.14-0.87, p = 0.024). Cox regression showed lower adjusted hazard ra...Continue Reading

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Citations

May 2, 2018·Neurology·Brian C Callaghan, Kevin A Kerber
Aug 11, 2020·Stroke; a Journal of Cerebral Circulation·Alain LekoubouPaddy Ssentongo
Feb 11, 2020·Frontiers in Neurology·Rosane BrondaniMarino Muxfeldt Bianchin
Dec 5, 2019·NeuroImage. Clinical·John-Paul NicoloPatrick Kwan
Sep 11, 2021·Annals of Neurology·Carolina Ferreira-AtuestaMarian Galovic
Oct 1, 2021·Frontiers in Aging Neuroscience·Ru LinXinshi Wang

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