Association between in vivo alcohol metabolism and genetic variation in pathways that metabolize the carbon skeleton of ethanol and NADH reoxidation in the alcohol challenge twin study.

Alcoholism, Clinical and Experimental Research
Penelope A LindJohn B Whitfield

Abstract

Variation in alcohol metabolism affects the duration of intoxication and alcohol use. While the majority of genetic association studies investigating variation in alcohol metabolism have focused on polymorphisms in alcohol or aldehyde dehydrogenases, we have now tested for association with genes in alternative metabolic pathways that catalyze the carbon skeleton of ethanol (EtOH) and NADH reoxidation. Nine hundred fifty single nucleotide polymorphisms (SNPs) spanning 14 genes (ACN9, ACSS1, ACSS2, ALDH1A1, CAT, CYP2E1, GOT1, GOT2, MDH1, MDH2, SLC25A10, SLC25A11, SLC25A12, SLC25A13) were genotyped in 352 young adults who participated in an alcohol challenge study. Traits tested were blood alcohol concentration (BAC), breath alcohol concentration (BrAC), peak alcohol concentration, and rates of alcohol absorption and elimination. Allelic association was tested using quantitative univariate and multivariate methods. A CYP2E1 promoter SNP (rs4838767, minor allele frequency 0.008) exceeded the threshold for study-wide significance (4.01 × 10(-5) ) for 2 early BAC, 8 BrAC measures, and the peak BrAC. For each phenotype, the minor C allele was related to a lower alcohol concentration, most strongly for the fourth BrAC (p = 2.07 × 10(-7...Continue Reading

References

Aug 1, 1975·The Biochemical Journal·A J MeijerJ M Tager
Apr 1, 1992·Pharmacogenetics·D P Agarwal, H W Goedde
Aug 1, 1992·Pharmacogenetics·A Yoshida
Mar 1, 1985·Behavior Genetics·N G MartinA V Wilks
Feb 1, 1972·The Biochemical Journal·K O LindrosO A Forsander
Mar 1, 1971·Clinical Pharmacology and Therapeutics·E S VesellG T Passananti
Jan 1, 1994·Journal of Toxicology. Clinical Toxicology·C S Lieber
Feb 26, 1998·Alcohol·W E Lands
Nov 5, 1998·Alcoholism, Clinical and Experimental Research·J B WhitfieldN G Martin
Apr 2, 1999·European Journal of Biochemistry·R A Dennis, M T McCammon
Jul 9, 1999·Alcoholism, Clinical and Experimental Research·C S Lieber
Jan 13, 2000·American Journal of Human Genetics·G R AbecasisW O Cookson
Jul 25, 2000·Journal of Clinical Pharmacy and Therapeutics·E TanakaS Misawa
Aug 17, 2001·Annals of Neurology·G P ComiN Bresolin
Jan 5, 2002·Pathologie-biologie·D P Agarwal
Dec 20, 2003·Nature·UNKNOWN International HapMap Consortium
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Sep 17, 2004·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·S RaimondiE Taioli
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Cindy L EhlersLucinda G Carr
Dec 21, 2004·Alcoholism, Clinical and Experimental Research·Marc A SchuckitSandra A Brown
Mar 31, 2006·Human Molecular Genetics·Howard J EdenbergTatiana Foroud
Jun 24, 2006·Alcoholism, Clinical and Experimental Research·Peter A DicksonAndrew J Birley
Oct 9, 2007·Human Molecular Genetics·Andrew J BirleyNicholas G Martin
May 27, 2008·Nature Genetics·Mia HashibePaul Brennan
Nov 21, 2008·Bioinformatics·Manuel A R Ferreira, Shaun M Purcell
Jan 6, 2009·Current Drug Abuse Reviews·Xin-sheng Deng, Richard A Deitrich
Feb 6, 2009·Human Molecular Genetics·Andrew J BirleyJohn B Whitfield
Apr 10, 2009·Legal Medicine·Ameno KiyoshiKinoshita Hiroshi
Nov 10, 2009·American Journal of Human Genetics·Sarah E MedlandNicholas G Martin
Mar 6, 2010·Alcoholism, Clinical and Experimental Research·Geoff JoslynRaymond L White

❮ Previous
Next ❯

Citations

Jan 8, 2014·Molecular Genetics and Genomics : MGG·Tatiana V MorozovaRobert R H Anholt
Aug 26, 2014·Basic & Clinical Pharmacology & Toxicology·Jaroslav A HubacekSergey Zakharov
Oct 16, 2015·Addiction Biology·Renato PolimantiJoel Gelernter
Sep 4, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Fengmao Li, Yunming Tang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.