Association Between Increased Vascular Nitric Oxide Bioavailability and Progression to Dengue Hemorrhagic Fever in Adults

The Journal of Infectious Diseases
Tun-Linn TheinTsin W Yeo

Abstract

In a prospective longitudinal adult study, vascular nitric oxide bioavailability measured as reactive hyperemia index was significantly higher at enrollment in patients who developed dengue hemorrhagic fever (DHF) (n = 11), compared with the non-DHF group (n = 63) and those with other febrile illnesses (n = 25) (P = .01). After adjustment for age, fever day, and body mass index, enrollment reactive hyperemia index was associated with a 4-fold increased risk for DHF, and predicted DHF with an area under the receiver operating curve of 0.86. Increased vascular nitric oxide in dengue is associated with increased vascular permeability and impaired homeostasis and may have utility as a predictor of DHF.

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Apr 25, 2017·Immunology·Gathsaurie Neelika Malavige, Graham S Ogg
Oct 27, 2015·Immunological Reviews·Adam TaylorSuresh Mahalingam
Jul 5, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sophie YacoubBridget Wills
May 16, 2018·Frontiers in Medicine·Eugenio D HottzPatrícia T Bozza
Jan 11, 2020·Frontiers in Microbiology·Lifen HanHanhui Ye

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