Association between individual and combined SNPs in genes related to innate immunity and incidence of CMV infection in seropositive kidney transplant recipients

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Mario Fernández-RuizOPERA Study Group

Abstract

In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved in orchestrating the immune response against cytomegalovirus (CMV) and the 12-month incidence of CMV infection in 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. CMV infection occurred in 140 patients (44.4%), including 13 episodes of disease. After adjusting for various clinical covariates, patients harboring T-allele genotypes of interleukin-28B (IL28B) (rs12979860) SNP had lower incidence of CMV infection (adjusted hazard ratio [aHR]: 0.66; 95% confidence interval [CI]: 0.46-0.96; p-value = 0.029). In the analysis restricted to patients not receiving prophylaxis, carriers of the TT genotype of toll-like receptor 9 (TLR9) (rs5743836) SNP had lower incidence of infection (aHR: 0.61; 95% CI: 0.38-0.96; p-value = 0.035), whereas the GG genotype of dendritic cell-specific ICAM 3-grabbing nonintegrin (DC-SIGN) (rs735240) SNP exerted the opposite effect (aHR: 1.86; 95% CI: 1.18-2.94; p-value = 0.008). An independent association was found between the number of unfavorable SNP genotypes carried by the patient and the incidence o...Continue Reading

References

Mar 29, 2003·Journal of Virology·Teresa ComptonRobert W Finberg
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Koichi TabetaBruce Beutler
Jan 18, 2006·American Journal of Epidemiology·Thomas A TrikalinosJohn P A Ioannidis
Jan 24, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HumarUNKNOWN AST ID Working Group on Infectious Disease Monitoring
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karl W BoehmeTeresa Compton
Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Supha KijpittayaritRaymund R Razonable
Dec 14, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M MezgerJ Loeffler
Feb 6, 2009·PLoS Medicine·Julian LittleUNKNOWN STrengthening the REporting of Genetic Association Studies
Mar 21, 2009·European Journal of Clinical Investigation·Julian LittleNick Birkett
Sep 18, 2009·Nature·David L ThomasMary Carrington
Oct 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Carlos CerveraMiquel Navasa
Oct 10, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert A BrownRaymund R Razonable
Oct 22, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R B Freeman
Jan 18, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Dimitra MitsaniCornelius J Clancy
Sep 20, 2011·Enfermedades infecciosas y microbiología clínica·Julian de la Torre-CisnerosUNKNOWN GESITRA-SEIMC/REIPI
May 23, 2012·Nature Immunology·Mihai G NeteaLuke A J O'Neill
Oct 3, 2012·PloS One·Stephanie TraubLena Alexopoulou
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R R RazonableUNKNOWN AST Infectious Diseases Community of Practice
Jul 31, 2013·Transplantation·Camille N KottonUNKNOWN Transplantation Society International CMV Consensus Group
Mar 13, 2014·The Journal of Infectious Diseases·Adrian EgliAtul Humar

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Citations

Dec 19, 2015·Journal of Medical Virology·David Navarro
Dec 28, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Muhtashim MianDeepali Kumar
Mar 30, 2018·Transplantation·Camille N KottonUNKNOWN The Transplantation Society International CMV Consensus Group
Nov 1, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mario Fernández-RuizOriol Manuel
Oct 28, 2018·Mycoses·Tertuliano Alves Pereira NetoLuiz Cosme Cotta Malaquias
Mar 28, 2017·Virology Journal·Wioletta WujcickaDorota Nowakowska
Aug 10, 2019·Frontiers in Genetics·Efe SezginCheryl A Winkler
Mar 13, 2018·The Journal of Clinical Investigation·Kang YuDeborah N Burshtyn
Jun 6, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Klara ChmelovaJan Sperl
Aug 28, 2020·Frontiers in Cellular and Infection Microbiology·Giada FrascaroliStefania Varani
Oct 5, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Amit D RavalDavid R Snydman

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