Abstract
Coronary artery spasm is an important pathophysiological mechanism in some forms of myocardial ischemic disease. The relationship between inflammatory markers, mean platelet volume (MPV), and coronary artery spasm is unclear. During coronary angiography, methylergometrin was injected intravenously to 345 patients with chest pain but without significant coronary disease on angiogram to provoke coronary artery spasm. Based on provocation test results, patients were divided into 2 groups: spasm group (60 patients) and nonspasm group (285 patients). Inflammatory markers (C-reactive protein, CRP; white blood cells; polymorphonuclear neutrophils, PMN; monocytes, MO; lymphocytes, LY), hemostasis markers (MPV; platelet count; fibrinogen [FIB]; D-dimers), and traditional risk factors (body mass index; hyperlipidemia; triglycerides [TGs]; total, low-density, and high-density lipoprotein cholesterol [TC, LDL-C, and HDL-C]) were measured and compared between groups. More male patients experienced spasm (23.56% vs. 11.11%, P = 0.002). CRP, PMN, and MO were significantly higher in the spasm group (P < 0.05). There was no significant difference in serum levels of LDL-C, HDL-C, TG, TC, LY, MPV, and FIB between groups. Smoking and hyperlipidemi...Continue Reading
References
Sep 1, 1994·Cardiovascular Research·J J LiuB F Buxton
Feb 1, 1996·The Journal of Clinical Investigation·H ShimokawaA Takeshita
Dec 31, 1998·American Journal of Respiratory Cell and Molecular Biology·T TerashimaS F van Eeden
Feb 2, 1999·Respiration Physiology·S BergmannW Jaross
Jun 30, 2000·Japanese Circulation Journal·S SuedaT Uraoka
Jan 25, 2002·Annals of the New York Academy of Sciences·L Robbie, P Libby
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
Jun 19, 2002·Trends in Cardiovascular Medicine·Burkhard LudewigHans Hengartner
Feb 1, 2003·Japanese Heart Journal·Johann AuerBernd Eber
Sep 15, 2004·Cardiovascular Research·Brian R ClappRaymond J MacAllister
Jun 7, 2005·Thrombosis Research·Alexander YangBerndt Lüderitz
Nov 3, 2005·Nature Clinical Practice. Cardiovascular Medicine·Subodh VermaPaul M Ridker
Jan 10, 2006·Clinical Science·Gordon D O Lowe
Jan 31, 2006·Journal of Clinical Pathology·M M KhandekarA K Inamdar
Jul 19, 2006·Hypertension·Yun ZhongSubodh Verma
Jun 26, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Teruhiko ItohHirofumi Yasue
Nov 29, 2007·Cerebrovascular Diseases·Lina Badimon, Gemma Vilahur
Aug 21, 2009·Journal of Thrombosis and Haemostasis : JTH·S G ChuJ S Berger
Oct 31, 2009·Journal of Thrombosis and Haemostasis : JTH·S J Machin, C Briggs
Dec 2, 2009·Korean Circulation Journal·Ju Hwan LeeWee-Hyun Park
Dec 25, 2009·Circulation. Cardiovascular Interventions·Hitoshi NakagawaHirofumi Yasue
Aug 20, 2010·European Journal of Clinical Investigation·Ming-Yow HungWen-Jin Cherng
Nov 9, 2010·American Journal of Physiology. Heart and Circulatory Physiology·M A Hassan TalukderJay L Zweier
Dec 17, 2010·World Journal of Cardiology·Ming-Jui Hung
Mar 11, 2011·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yoshiki KusamaKyoichi Mizuno
Mar 12, 2011·Coronary Artery Disease·Shigemasa TaniAtsushi Hirayama
Aug 30, 2011·European Heart Journal·Christian W HammUNKNOWN ESC Committee for Practice Guidelines
Sep 10, 2011·Journal of the American College of Cardiology·Yoku KikuchiHiroaki Shimokawa
Oct 19, 2011·Circulation·Gaetano Antonio LanzaFilippo Crea
Citations
May 28, 2014·Journal of Interventional Cardiology·Cengiz Beyan, Esin Beyan
Mar 31, 2015·BMJ Case Reports·Hazlyna KamaruddinJulian Gunn
Oct 23, 2019·BioMed Research International·Liang LiChao Feng
Jun 23, 2018·Journal of Burn Care & Research : Official Publication of the American Burn Association·Derek M Culnan, Rajiv Sood
Feb 14, 2021·Scientific Reports·Ye-Fei LiZhen-Qiang Sheng
Jul 20, 2021·International Heart Journal·Qing ZhangZhen-Qiang Sheng