Association between inflammatory markers, hemostatic markers, and traditional risk factors on coronary artery spasm in patients with normal coronary angiography

Journal of Interventional Cardiology
Ailiman MahemutiNicolas Meneveau

Abstract

Coronary artery spasm is an important pathophysiological mechanism in some forms of myocardial ischemic disease. The relationship between inflammatory markers, mean platelet volume (MPV), and coronary artery spasm is unclear. During coronary angiography, methylergometrin was injected intravenously to 345 patients with chest pain but without significant coronary disease on angiogram to provoke coronary artery spasm. Based on provocation test results, patients were divided into 2 groups: spasm group (60 patients) and nonspasm group (285 patients). Inflammatory markers (C-reactive protein, CRP; white blood cells; polymorphonuclear neutrophils, PMN; monocytes, MO; lymphocytes, LY), hemostasis markers (MPV; platelet count; fibrinogen [FIB]; D-dimers), and traditional risk factors (body mass index; hyperlipidemia; triglycerides [TGs]; total, low-density, and high-density lipoprotein cholesterol [TC, LDL-C, and HDL-C]) were measured and compared between groups. More male patients experienced spasm (23.56% vs. 11.11%, P = 0.002). CRP, PMN, and MO were significantly higher in the spasm group (P < 0.05). There was no significant difference in serum levels of LDL-C, HDL-C, TG, TC, LY, MPV, and FIB between groups. Smoking and hyperlipidemi...Continue Reading

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Citations

May 28, 2014·Journal of Interventional Cardiology·Cengiz Beyan, Esin Beyan
Mar 31, 2015·BMJ Case Reports·Hazlyna KamaruddinJulian Gunn
Oct 23, 2019·BioMed Research International·Liang LiChao Feng
Jun 23, 2018·Journal of Burn Care & Research : Official Publication of the American Burn Association·Derek M Culnan, Rajiv Sood
Feb 14, 2021·Scientific Reports·Ye-Fei LiZhen-Qiang Sheng

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