Association between insulin resistance and endothelial dysfunction in renal transplant recipients

Clinical Transplantation
Monica H VoytovichAnders Hartmann

Abstract

Endothelial dysfunction is a common finding in renal transplant recipients (RTR) and is related to impaired local regulation of vasodilative and vasoconstrictive substances, such as nitric monoxide (NO) and endothelin-1 (ET-1). In non-transplanted patients, an association between impaired endothelial function and insulin resistance has been shown. Whether such an association also exists in RTR is unknown. The aim of the present study was to examine whether insulin resistance is associated with endothelial dysfunction in RTR. A total of 47 RTR in a stable phase six yr post-transplant were included in the statistical analysis. The immunosuppressive therapy was based on cyclosporine and prednisolone. Non-invasive assessment of endothelial function was performed with laser Doppler flowmetry of the forearm skin vasculature after local acetylcholine stimulation. Oral glucose tolerance tests comprising both glucose and insulin measurements were used to calculate insulin sensitivity (IS) indices. NO, ET-1 and von Willebrand factor were measured in fasting plasma samples. Normal glucose tolerance was found in 31 RTR. In these subjects, both IS (r(2) = 0.164, p = 0.044) and plasma NO (r(2) = 0.326, p = 0.002) were significantly correlate...Continue Reading

References

Mar 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M LaaksoL Mykkänen
Aug 1, 1987·Diabetes·H Yki-JärvinenV A Koivisto
Sep 1, 1997·The Journal of Clinical Investigation·H O SteinbergA D Baron
Mar 18, 2000·Kidney International·S T MorrisA G Jardine
Jun 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A AsbergA Hartmann
Aug 28, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A AsbergH Holdaas
Jul 11, 2002·Diabetologia·H O Steinberg, A D Baron
Sep 6, 2003·The American Journal of Cardiology·Willa A Hsueh, Manuel J Quiñones
Sep 10, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Hannele Yki-Järvinen
Sep 19, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Monica HagenAnders Hartmann
Dec 24, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Monica Hagen VoytovichAnders Hartmann

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Citations

Feb 24, 2007·Transplantation·Kayser CaglarMujdat Yenicesu
Feb 1, 2013·Transplantation·Dag Olav DahleAnders Asberg
Jan 29, 2008·Nephron. Clinical Practice·Mhairi K Sigrist, Christopher W McIntyre
Jan 24, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thea Anine Strøm HaldenTrond Jenssen
Feb 12, 2010·Scandinavian Journal of Medicine & Science in Sports·D B OlsenF Dela

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