Association between interleukin-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

Bioscience Reports
Kewei RenXiaolong Li

Abstract

Controversial results concerning the association between a polymorphism rs6822844 in the interleukin (IL) 21 (IL-21) gene and rheumatoid arthritis (RA) have existed. A meta-analysis to confirm above relationships is necessary to be performed immediately. We conducted a search in the PubMed database, covering all papers published up to 20 October 2018. Overall, six case-control studies with 3244 cases and 3431 healthy controls were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of this association. Publication bias was assessed with both Egger's and Begg's tests. After calculation, we found that IL-21 rs6822844 polymorphism could decrease RA risk in overall genetic models (allelic contrast: OR = 0.77, 95% CI = 0.62-0.97, P=0.024; TG versus GG: OR = 0.68, 95% CI = 0.50-0.92, P=0.013, and dominant genetic model: OR = 0.72, 95% CI = 0.55-0.94, P=0.016). Similarly, stratified analysis by race, source of control, significantly decreased association was found in Asians, Caucasians and hospital-based (HB) control source. Finally, in the subgroup analysis of rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) status, poorly decreased relationship was detected between IL-...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Aug 16, 2003·Developmental Cell·Hristo B HoubaviyPhillip A Sharp
Oct 2, 2004·Annals of the Rheumatic Diseases·E LindqvistT Saxne
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xuezhong CaiBryan R Cullen
Sep 3, 2005·Nature Reviews. Immunology·Warren J Leonard, Rosanne Spolski
Nov 9, 2005·Journal of Epidemiology·Yasuaki HayashinoTsuguya Fukui
Feb 12, 2008·Rheumatology·J Bowes, A Barton
Mar 24, 2009·Arthritis Research & Therapy·Vitor Hugo TeixeiraUNKNOWN European Consortium on Rheumatoid Arthritis Families
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eunkyeong JangJeehee Youn
May 1, 2009·Arthritis and Rheumatism·Nina A DahaRené E M Toes
Sep 12, 2009·Tissue Antigens·C O'DohertyK Vandenbroeck
Jan 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeong-su DoBooki Min
Feb 4, 2010·Seminars in Immunopathology·Erik Lubberts
Feb 12, 2010·Annals of the New York Academy of Sciences·Jan Davidson-MoncadaWayne Tam
Mar 1, 2011·Human Immunology·F David CarmonaMiguel A González-Gay
Sep 10, 2015·Arthritis Research & Therapy·H W van SteenbergenA H M van der Helm-van Mil
Nov 30, 2016·Scandinavian Journal of Immunology·A Paradowska-GoryckaM Olesinska
Feb 6, 2017·Nature Reviews. Rheumatology·Medya M ShikhagaieHergen Spits
Feb 28, 2017·Mediators of Inflammation·Yong TanCheng Xiao
May 27, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Isaura Isabelle Fonseca Gomes da SilvaPaulo Roberto Eleuterio de Souza
Aug 11, 2017·Nature Reviews. Rheumatology·Leendert A TrouwAnna M Blom
Sep 9, 2017·Archives of Medical Science : AMS·Damian MalinowskiAndrzej Pawlik

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Methods Mentioned

BETA
genotyping

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String
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1000 Genomes Browser

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