Association Between Interleukin-6 -572 C>G and -174 G>C Polymorphisms and Hypertension: A Meta-analysis of Case-control Studies

Medicine
He MaZhaojun Lu

Abstract

Whether hypertension is associated with -572 C>G or -174 G>C polymorphism in interleukin (IL)-6 genes still remains hazy and ambiguous.We conducted a meta-analysis to offer a more reliable and clearer evaluation about the association.Electronic literature databases including PubMed, Web of Science, EMBASE, Google Scholar, Chinese National Knowledge Infrastructure and Wanfang database were searched.The study included the following: evaluating associations between -572 C>G or -174 G>C polymorphism in IL-6 gene and hypertension; case-control design; essential information must be offered; precise diagnostic criteria of hypertension; and no language restriction.Patients who met the diagnostic criteria and controls without a history of hypertension were included. Interventions were not available.A quality assessment was conducted using Newcastle-Ottawa scale. Combined odds ratios with 95% confidence intervals were calculated in 5 genetic models. Sources of heterogeneity were explored by subgroup analysis, meta-regression, and Galbraith plots. Finally, test for publication bias was performed to prove the stabilization.Fifteen studies were finally included. Eleven articles were judged high-quality reports. Overall, the -572 C>G polymor...Continue Reading

References

Mar 20, 1998·International Reviews of Immunology·T Hirano
Apr 5, 2000·The Journal of Biological Chemistry·C F TerryF R Green
Feb 13, 2001·European Journal of Clinical Investigation·A C PeetersT Thien
Aug 4, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J L GeorgesL Tiret
Nov 9, 2002·Lancet·Majid EzzatiUNKNOWN Comparative Risk Assessment Collaborating Group
Jun 6, 2003·Endocrine Reviews·José Manuel Fernández-Real, Wifredo Ricart
Jul 10, 2003·JAMA : the Journal of the American Medical Association·Ihab Hajjar, Theodore A Kotchen
Nov 19, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jie DongAkira Kitabatake
Apr 20, 2004·Japanese Heart Journal·Tsugiyasu Kanda, Takashi Takahashi
Sep 14, 2004·Journal of Human Hypertension·M O M Tanira, K A Al Balushi
Jan 5, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sudhir JainAshok Kumar
Jan 18, 2005·Lancet·Patricia M KearneyJiang He
Mar 23, 2005·Medical Hypotheses·Jian-Jun Li, Ji-Lin Chen
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Jun 23, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chihiro TanakaHitonobu Tomoike
Jun 28, 2005·Clinical and Experimental Nephrology·Florian LangSiegfried Waldegger
Dec 14, 2005·Statistics in Medicine·Roger M HarbordJonathan A C Sterne
Mar 6, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jean Kyung PaikJong Ho Lee
May 4, 2007·American Journal of Physiology. Cell Physiology·Sudhir JainAshok Kumar
Sep 6, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yasuaki SaijoReiko Kishi
Nov 13, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A C TonetO T Nóbrega
Nov 14, 2007·Metabolism: Clinical and Experimental·Estibaliz GoyenecheaJ Alfredo Martínez
Dec 11, 2008·Vascular Health and Risk Management·Mark P S SieJacqueline C M Witteman
Mar 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio OgiharaUNKNOWN COLM study investigators
Mar 17, 2009·International Journal of Molecular Medicine·Xiuqin ZhangHong-Tao Zhang

❮ Previous
Next ❯

Citations

Apr 13, 2017·Frontiers in Aging Neuroscience·Alix L de DieuleveultAnne-Marie Brouwer
Aug 31, 2017·Oxidative Medicine and Cellular Longevity·Ioana Corina BocsanAnca Dana Buzoianu
Jun 13, 2019·International Journal of Hypertension·Daniela Maria TanaseMariana Floria
May 16, 2020·Frontiers in Neuroscience·Sulin ZhangWeijia Kong
Feb 7, 2019·The Pharmacogenomics Journal·Santiago CuevasPedro A Jose
Jan 14, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Nader SalariAliakbar Vaisi-Raygani

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

MassARRAY
Excel
Google Scholar
EndNote
Stata

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.