Association Between Interleukin-6 and Striatal Prediction-Error Signals Following Acute Stress in Healthy Female Participants

Biological Psychiatry
Michael T TreadwayDiego A Pizzagalli

Abstract

Stress is widely known to alter behavioral responses to rewards and punishments. It is believed that stress may precipitate these changes through modulation of corticostriatal circuitry involved in reinforcement learning and motivation, although the intervening mechanisms remain unclear. One candidate is inflammation, which can rapidly increase following stress and can disrupt dopamine-dependent reward pathways. Here, in a sample of 88 healthy female participants, we first assessed the effect of an acute laboratory stress paradigm on levels of plasma interleukin-6 (IL-6), a cytokine known to be both responsive to stress and elevated in depression. In a second laboratory session, we examined the effects of a second laboratory stress paradigm on reward prediction error (RPE) signaling in the ventral striatum. We show that individual differences in stress-induced increases in IL-6 (session 1) were associated with decreased ventral striatal RPE signaling during reinforcement learning (session 2), though there was no main effect of stress on RPE. Furthermore, changes in IL-6 following stress predicted intraindividual variability in perceived stress during a 4-month follow-up period. Taken together, these data identify a novel link b...Continue Reading

Citations

Jul 26, 2018·The European Journal of Neuroscience·Maria M DiehlDavid V Smith
Jun 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Steven J ShabelRoberto Malinow
Sep 21, 2019·Translational Psychiatry·Guia GuffantiDiego A Pizzagalli
Dec 9, 2020·Current Psychiatry Reports·Robert D LevitanStephen G Matthews
Dec 21, 2020·Brain and Cognition·Joana CarvalheiroAna Seara-Cardoso
Jan 29, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Alexis E WhittonDiego A Pizzagalli
Sep 13, 2020·Brain, Behavior, and Immunity·Manivel RengasamyRebecca B Price
Apr 5, 2018·Biological Psychiatry·Andre Der-Avakian, Diego A Pizzagalli
Mar 6, 2018·Current Opinion in Behavioral Sciences·Jessica A CooperMichael T Treadway
Jul 20, 2021·Behavioural Brain Research·Liisa Hantsoo, Babette S Zemel
Nov 12, 2021·Neurobiology of Stress·Joana CarvalheiroAna Seara-Cardoso

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