Association between interleukin-6 gene -174 G/C polymorphism and the risk of coronary heart disease: a meta-analysis of 20 studies including 9619 cases and 10,919 controls

Gene
Yan-Wei YinMing-qi Zhou

Abstract

Interleukin-6 (IL-6) gene -174 G/C polymorphism has been reported to be associated with coronary heart disease (CHD), but the results remain inconclusive. The present meta-analysis was therefore designed to clarify these controversies. This meta-analysis was performed by searching PubMed, Embase and Web of Science databases. A total of 20 studies including 9619 CHD cases and 10,919 controls were combined showing no evidence of association between IL-6 gene -174 G/C polymorphism and CHD risk (for C/C+C/G vs. G/G: OR=1.10, 95% CI=0.99-1.22, p=0.07; for C/C vs. C/G+G/G: OR=1.08, 95% CI=0.93-1.24, p=0.33; for C/C vs. G/G: OR=1.16, 95% CI=0.97-1.39, p=0.11; for C allele vs. G allele: OR=1.10, 95% CI=1.00-1.21, p=0.06). Moreover, we also did not find significant association between IL-6 gene -174 G/C polymorphism and myocardial infarction (MI) risk. However, in the subgroup analysis by ethnicity, significant association was found among Asians (for C/C+C/G vs. G/G: OR=1.35, 95% CI=1.05-1.63, p=0.02). In summary, the present meta-analysis suggests that IL-6 gene -174 G/C polymorphism is associated with increased CHD risk among Asians. However, due to the small subjects included in the subgroup analysis of Asians, the results should be ...Continue Reading

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Citations

Mar 27, 2015·The Journal of Obstetrics and Gynaecology Research·Qiongyao WangZhijiao Song
Aug 8, 2014·Frontiers in Immunology·Natalia Castaño-RodríguezHazel M Mitchell
Sep 22, 2016·The FEBS Journal·Özge Uluçkan, Erwin F Wagner
Nov 15, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Su Kang KimOh Young Kwon
Jul 25, 2013·The Journal of International Medical Research·Zichuan TongXinchun Yang
Aug 19, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Lu KouQin Qin
Aug 26, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jing-Fang LiYong Yin
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Dec 19, 2020·Open Medicine·He-Guo DingSun-Lin Liu
Oct 2, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Himanshu RaiRobert A Byrne

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