Association between interleukin-6 polymorphisms and periodontitis in Indian non-smokers

Journal of Clinical Periodontology
Fernando Franch-ChillidaPeter M Brett

Abstract

Genetic polymorphisms (SNPs) in the interleukin-6 (IL-6) gene have been associated with the presence of periodontitis. The aim of this study was to investigate the association between five SNPs in the IL-6 promoter region and the periodontal status of a rural Indian population. Two hundred and fifty-one systemically healthy volunteers were clinically assessed by a single calibrated examiner and divided into: healthy individuals and periodontitis patients based on the European Workshop on Periodontitis definitions and on a recently suggested definition, which takes into account age and clinical attachment levels. Their genomic DNA was analysed blindly using real-time polymerase chain reaction to study IL-6 variants. The association between genetic factors and the presence of periodontitis was assessed by logistic regression. The IL-6-174 GG genotype was associated with periodontitis in non-smokers and older subjects (>45 years old). No statistically significant associations were detected between IL-6 haplotypes and periodontal status, after adjusting for confounders. The IL-6-174 polymorphism showed some evidence of an association with the periodontal status in non-smokers and older subjects in this rural Indian population. This...Continue Reading

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Citations

Nov 30, 2011·Journal of Periodontology·Kohei IshidaHiromasa Yoshie
Apr 22, 2014·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Amit Arvind Agrawal
Dec 31, 2014·Molecular Biology International·Fernanda Gabriela TeixeiraRaquel de Souza Gestinari
Dec 14, 2011·Clinical Oral Implants Research·Xanthippi DerekaNikolaos Donos
Nov 5, 2011·Oral Diseases·L NibaliN Donos
Aug 4, 2020·Journal of Leukocyte Biology·Ying ZhengWai Keung Leung

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