Association between intestinal vitamin D receptor, calcium absorption, and serum 1,25 dihydroxyvitamin D in normal young and elderly women

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
H K KinyamuS J Lanspa

Abstract

The exact mechanism for the decrease in intestinal calcium absorption with age is not yet understood. A decrease with age in serum 1,25-dihydroxyvitamin D (1,25(OH)2D) or a decrease in the intestinal vitamin D receptor (VDR) protein concentration are possible causes. The objective of this study was to examine the effect of age on these factors. Fifty-nine young women age 25-35 years were compared with 41 elderly women age 65-83 years who underwent measurements of VDR, calcium absorption using a 20 mg and 100 mg calcium carrier, and calciotropic hormones. Calcium absorption by both tests was lower in the elderly women compared with the young women (p < 0.05). Serum 1,25(OH)2D and duodenal VDR protein concentration were not significantly different between the two age groups. Serum 1,25(OH)2D correlated with the 20 mg calcium absorption test in both young (r = 0.35, p < 0.007) and elderly women (r = 0.58, p < 0.0001) and with the 100 mg calcium absorption in the elderly (r = 0.32; p < 0.05). VDR did not correlate with calcium absorption in young women or elderly women, nor did VDR correlate with serum 1,25(OH)2D and serum 25-hydroxyvitamin D. In summary, the decrease in calcium absorption cannot be explained by a decrease in intes...Continue Reading

References

Jan 1, 1991·Annual Review of Nutrition·J W Pike
Feb 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R EastellB L Riggs
Apr 23, 1990·Biochimica Et Biophysica Acta·S TakamotoC T Liang
Nov 1, 1990·The Journal of Clinical Endocrinology and Metabolism·C GennariR Civitelli
Aug 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S S ShermanJ D Tobin
Nov 15, 1989·Analytical Biochemistry·M E Sandgren, H F Deluca
Dec 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P P Minghetti, A W Norman
Oct 1, 1985·The Journal of Clinical Investigation·J MacLaughlin, M F Holick
Jun 13, 1986·Biochemical and Biophysical Research Communications·E M Costa, D Feldman
Jan 1, 1986·Annual Review of Nutrition·M R Haussler
Jan 1, 1988·The Journal of Clinical Investigation·M S SheikhJ S Fordtran
Sep 1, 1986·The Journal of Clinical Endocrinology and Metabolism·T L ClemensR Lindsay
Mar 1, 1986·Seminars in Nephrology
Jan 1, 1986·Bone·S EpsteinC C Johnston
Sep 12, 1970·Lancet·J R BullamoreD H Marshall
Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J G Haddad, K J Chyu
Nov 1, 1973·The Journal of Clinical Investigation·P Ireland, J S Fordtran
Dec 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J C GallagherH F DeLuca
Jan 1, 1983·Annual Review of Biochemistry·H F DeLuca, H K Schnoes
Jun 1, 1984·The Journal of Clinical Investigation·K S TsaiB L Riggs
Jan 1, 1984·Age and Ageing·R M FrancisS A Barkworth
Apr 1, 1983·The Journal of Clinical Endocrinology and Metabolism·S C ManolagasL J Deftos
Jan 1, 1984·The Journal of Clinical Endocrinology and Metabolism·T A ReinhardtB W Hollis
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J C GallagherB L Riggs
Apr 1, 1980·British Journal of Clinical Pharmacology·F J RowellD Eccleston
Aug 1, 1994·Bone and Mineral·B H ArjmandiD N Kalu
Apr 1, 1993·Bone and Mineral·B H ArjmandiD N Kalu

❮ Previous
Next ❯

Citations

Dec 19, 2008·Journal of Endocrinological Investigation·J A BalsaC Vázquez
May 10, 2003·Journal of Women's Health·Alan O Malabanan, Michael F Holick
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C GallagherS S Sherman
May 13, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S K AmesS A Abrams
Jan 20, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E M ColinJ P Van Leeuwen
May 11, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L A RubinD E Cole
Apr 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A ShaoJ C Fleet
Jun 28, 2005·Aging Clinical and Experimental Research·Florent RichyJean-Yves Reginster
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R L Prince, I Dick
Jan 10, 2008·Biochemical and Biophysical Research Communications·Giana AngeloRichard J Wood
Apr 15, 1999·European Journal of Clinical Investigation·J R WaltersS Legon
Jul 25, 2000·European Journal of Clinical Investigation·B L LangdahlE F Eriksen
Jan 10, 2003·Journal of Cellular Biochemistry·B Lawrence Riggs
Jan 14, 2018·The Journal of Hand Surgery, European Volume·Kahyun KimGoo Hyun Baek
Feb 19, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H A Bischoff-FerrariW Dick
Sep 28, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Julian R F WaltersRichard Poulsom
Oct 16, 2007·Journal of Morphology·Katharina RinerAnnette Liesegang
Dec 14, 2017·The Proceedings of the Nutrition Society·Niamh AspellMaria O'Sullivan
May 10, 2007·Cells, Tissues, Organs·Alois BoosAnnette Liesegang
Oct 30, 2016·Bone Research·Vaishali VeldurthySylvia Christakos
Aug 21, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Rebecca A ReplogleJames C Fleet
Nov 11, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Lilian Mello SoaresLeonardo Souza Vasconcellos
Oct 14, 2016·Current Osteoporosis Reports·Daniele BellaviaGianluca Giavaresi
Jan 30, 2002·The American Journal of Clinical Nutrition·Amanda DevineRichard L Prince
Mar 14, 2018·Archives of Osteoporosis·Kahyun KimGoo Hyun Baek
Jul 3, 2020·Journal of Osteoporosis·Hitesh Kumar BhattaraiRosy Shakya
Jul 18, 2003·European Journal of Gastroenterology & Hepatology·Julian R Walters
Sep 28, 2004·The American Journal of Clinical Nutrition·B E Christopher NordinMichael Horowitz
Nov 7, 2000·Maturitas·M Dijkgraaf-ten BolscherJ C Netelenbos
Aug 19, 2007·Experimental Gerontology·Giovanni PasseriUNKNOWN Italian Multicentric Study on Centenarians (IMUSCE)
Jul 6, 2010·Archives of Biochemistry and Biophysics·Maria Luisa Bianchi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
A ShaoJames C Fleet
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
S A ShapsesL Taich
© 2021 Meta ULC. All rights reserved