Association between joint hypermobility syndrome and panic disorder: a case-control study

Psychosomatics
Javier García CampayoNatalia Sobradiel

Abstract

A significant association between joint hypermobility syndrome (JHS) and panic disorder was observed in a sample of rheumatology outpatients. The aim of this study was to assess whether JHS is more frequent in panic-disorder than in control subjects. The authors conducted a case-control study comparing 55 untreated patients with panic disorder and three matched-control groups: psychiatric patients, fibromyalgia patients, and healthy persons. JHS was more frequent among panic-disorder than among psychiatric patients, the healthy group, or the fibromyalgia group. In the panic-disorder group, there was a significant correlation between severity of JHS and anxiety. The strong association between JHS and panic disorder points to a genetic association. There is also a possibility that JHS and mitral valve prolapse, another condition frequently associated with panic disorder, share a common pathophysiological mechanism.

Citations

Oct 22, 2010·Current Psychiatry Reports·Javier Garcia-CampayoMarta Alda
Nov 4, 2011·The Journal of Nervous and Mental Disease·Guillem PailhezAntonio Bulbena
Sep 16, 2014·Journal of Psychosomatic Research·S B SanchesR Martín-Santos
Apr 28, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Jessica A EcclesHugo D Critchley
Apr 9, 2015·Frontiers in Neuroscience·Satoshi UmedaHugo D Critchley
Feb 26, 2015·Frontiers in Neuroscience·Jessica A EcclesHugo D Critchley

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